======= TMEM64 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM64
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 64
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=169200|169200]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6YI46|Q6YI46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM64&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM64|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620429|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1. {ECO:0000250|UniProtKB:Q3U145}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|positive regulation of osteoclast differentiation|
|positive regulation of tissue remodeling|
|regulation of bone resorption|
|negative regulation of osteoblast differentiation|
|regulation of bone remodeling|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of fat cell differentiation|
|regulation of osteoclast differentiation|
|negative regulation of ossification|
|regulation of tissue remodeling|
|regulation of ATPase activity|
|positive regulation of myeloid cell differentiation|
|regulation of osteoblast differentiation|
|regulation of myeloid leukocyte differentiation|
|regulation of fat cell differentiation|
|positive regulation of leukocyte differentiation|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of hemopoiesis|
|regulation of ossification|
|negative regulation of Wnt signaling pathway|
|regulation of myeloid cell differentiation|
|regulation of leukocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|regulation of cytosolic calcium ion concentration|
|regulation of Wnt signaling pathway|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of hemopoiesis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|endoplasmic reticulum|
|chemical homeostasis|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.63|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.04|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.83|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.88|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18667
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM64 Expression in NALM6 Cells: 3.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>