======= TMEM79 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM79
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 79
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84283|84283]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSE2|Q9BSE2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM79&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM79|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615531|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cuticle development|
|epithelial cell maturation|
|establishment of skin barrier|
|hair follicle morphogenesis|
|regulation of water loss via skin|
|epidermis morphogenesis|
|positive regulation of epidermis development|
|multicellular organismal water homeostasis|
|hair follicle development|
|skin epidermis development|
|water homeostasis|
|molting cycle process|
|hair cycle process|
|regulation of epidermis development|
|hair cycle|
|molting cycle|
|trans-Golgi network membrane|
|cornification|
|anatomical structure maturation|
|cell maturation|
|epithelial cell development|
|keratinization|
|developmental maturation|
|keratinocyte differentiation|
|lysosomal membrane|
|epidermal cell differentiation|
|multicellular organismal homeostasis|
|skin development|
|epidermis development|
|morphogenesis of an epithelium|
|regulation of body fluid levels|
|tissue morphogenesis|
|epithelial cell differentiation|
|regulated exocytosis|
|exocytosis|
|secretion by cell|
|export from cell|
|programmed cell death|
|identical protein binding|
|cell death|
|chemical homeostasis|
|epithelium development|
|secretion|
|positive regulation of developmental process|
|homeostatic process|
|cell development|
|tissue development|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.7|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.79|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.83|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.83|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.85|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.9|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.93|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|2|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.02|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.11|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3417
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM79 Expression in NALM6 Cells: 3.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>