======= TNFRSF10B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF10B
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 10b
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8795|8795]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14763|O14763]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF10B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF10B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603612|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:10542098, ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:15322075}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
|Death|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAIL-activated apoptotic signaling pathway|
|TRAIL binding|
|activation of NF-kappaB-inducing kinase activity|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of NIK/NF-kappaB signaling|
|cellular response to mechanical stimulus|
|NIK/NF-kappaB signaling|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|extrinsic apoptotic signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of NIK/NF-kappaB signaling|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of endopeptidase activity|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of peptidase activity|
|signaling receptor activity|
|response to mechanical stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of apoptotic signaling pathway|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cysteine-type endopeptidase activity|
|response to endoplasmic reticulum stress|
|apoptotic signaling pathway|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|activation of protein kinase activity|
|cellular response to external stimulus|
|positive regulation of proteolysis|
|leukocyte migration|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|cell migration|
|regulation of transferase activity|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|cell death|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.75|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|7.62|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|7.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fadd|FADD]]|0.682|
|[[:human genes:c:casp8|CASP8]]|0.644|
|[[:human genes:c:casp3|CASP3]]|0.625|
|[[:human genes:c:cxorf38|CXorf38]]|0.598|
|[[:human genes:c:ccnc|CCNC]]|0.442|
|[[:human genes:e:elavl1|ELAVL1]]|0.435|
|[[:human genes:f:fnip1|FNIP1]]|0.434|
|[[:human genes:i:ikzf2|IKZF2]]|0.432|
|[[:human genes:z:znf217|ZNF217]]|0.426|
|[[:human genes:t:trim25|TRIM25]]|0.426|
|[[:human genes:m:mtmr4|MTMR4]]|0.421|
|[[:human genes:f:flcn|FLCN]]|0.415|
|[[:human genes:z:zc3hav1|ZC3HAV1]]|0.414|
|[[:human genes:c:chd7|CHD7]]|0.413|
|[[:human genes:s:safb|SAFB]]|0.407|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3770
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF10B Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>