======= TNFRSF21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF21
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27242|27242]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75509|O75509]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605732|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:22761420, ECO:0000269|PubMed:9714541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-10 secretion|
|oligodendrocyte apoptotic process|
|negative regulation of interleukin-5 secretion|
|negative regulation of interleukin-13 secretion|
|glial cell apoptotic process|
|negative regulation of interleukin-5 production|
|negative regulation of interleukin-13 production|
|negative regulation of myelination|
|B cell apoptotic process|
|regulation of interleukin-5 secretion|
|regulation of interleukin-10 secretion|
|regulation of interleukin-13 secretion|
|negative regulation of B cell proliferation|
|lymphocyte apoptotic process|
|negative regulation of interleukin-10 production|
|regulation of interleukin-13 production|
|regulation of interleukin-5 production|
|neuron projection fasciculation|
|axonal fasciculation|
|leukocyte apoptotic process|
|negative regulation of nervous system process|
|negative regulation of B cell activation|
|intrinsic component of plasma membrane|
|regulation of oligodendrocyte differentiation|
|regulation of myelination|
|neuron apoptotic process|
|neuron recognition|
|neuron death|
|regulation of interleukin-10 production|
|negative regulation of T cell proliferation|
|regulation of B cell proliferation|
|negative regulation of cytokine secretion|
|regulation of glial cell differentiation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|myelination|
|ensheathment of neurons|
|axon ensheathment|
|negative regulation of T cell activation|
|regulation of gliogenesis|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of protein secretion|
|regulation of nervous system process|
|negative regulation of peptide secretion|
|negative regulation of lymphocyte activation|
|regulation of T cell proliferation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|T cell receptor signaling pathway|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|negative regulation of secretion|
|cell recognition|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|antigen receptor-mediated signaling pathway|
|axon|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of nervous system development|
|regulation of T cell activation|
|humoral immune response|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|axon development|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein secretion|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of lymphocyte activation|
|immune response-activating signal transduction|
|regulation of system process|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|positive regulation of immune response|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of protein localization|
|programmed cell death|
|cell death|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|integral component of plasma membrane|
|generation of neurons|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.7|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.7|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.97|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.97|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF21 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>