======= TNFRSF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF4
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7293|7293]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43489|P43489]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600315|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. {ECO:0000269|PubMed:7704935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tumor necrosis factor-activated receptor activity|
|positive regulation of immunoglobulin secretion|
|regulation of immunoglobulin secretion|
|T cell proliferation|
|positive regulation of B cell proliferation|
|positive regulation of immunoglobulin production|
|regulation of B cell proliferation|
|regulation of immunoglobulin production|
|negative regulation of cytokine secretion|
|virus receptor activity|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|viral entry into host cell|
|positive regulation of production of molecular mediator of immune response|
|leukocyte proliferation|
|entry into host|
|entry into host cell|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|negative regulation of protein secretion|
|positive regulation of leukocyte proliferation|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|interaction with host|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of B cell activation|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|viral life cycle|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|negative regulation of secretion|
|T cell activation|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|regulation of lymphocyte activation|
|cell population proliferation|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|positive regulation of cell population proliferation|
|leukocyte activation|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|cell activation|
|response to cytokine|
|negative regulation of molecular function|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|negative regulation of gene expression|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.03|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.02|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.96|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.91|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.89|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.88|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.75|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18526
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF4 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>