======= TNIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNIP2
  * **<color #00a2e8>Official Name</color>**: TNFAIP3 interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79155|79155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFZ5|Q8NFZ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610669|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EABR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD40 signaling pathway|
|toll-like receptor 2 signaling pathway|
|toll-like receptor 3 signaling pathway|
|toll-like receptor 9 signaling pathway|
|K63-linked polyubiquitin modification-dependent protein binding|
|positive regulation of macrophage activation|
|polyubiquitin modification-dependent protein binding|
|negative regulation of endothelial cell apoptotic process|
|negative regulation of epithelial cell apoptotic process|
|regulation of endothelial cell apoptotic process|
|regulation of macrophage activation|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of epithelial cell apoptotic process|
|interleukin-1-mediated signaling pathway|
|toll-like receptor signaling pathway|
|stress-activated MAPK cascade|
|pattern recognition receptor signaling pathway|
|stress-activated protein kinase signaling cascade|
|positive regulation of B cell activation|
|cellular response to interleukin-1|
|protein stabilization|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|regulation of B cell activation|
|cellular response to biotic stimulus|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|activation of innate immune response|
|protein deubiquitination|
|regulation of protein stability|
|protein modification by small protein removal|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of innate immune response|
|protein kinase binding|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|activation of immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of defense response|
|regulation of multi-organism process|
|response to lipid|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.57|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNIP2 Expression in NALM6 Cells: 4.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>