======= TNKS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNKS2
  * **<color #00a2e8>Official Name</color>**: tankyrase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80351|80351]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2K2|Q9H2K2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNKS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNKS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607128|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
|SAM 2|
|PARP|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein poly-ADP-ribosylation|
|protein auto-ADP-ribosylation|
|protein localization to chromosome, telomeric region|
|protein ADP-ribosylase activity|
|positive regulation of telomere capping|
|pericentriolar material|
|regulation of telomere capping|
|negative regulation of telomere maintenance via telomere lengthening|
|NAD+ ADP-ribosyltransferase activity|
|protein ADP-ribosylation|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomere maintenance via telomere lengthening|
|negative regulation of telomere maintenance|
|positive regulation of telomere maintenance|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|protein localization to chromosome|
|regulation of multicellular organism growth|
|positive regulation of DNA biosynthetic process|
|regulation of telomere maintenance|
|multicellular organism growth|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of chromosome organization|
|positive regulation of Wnt signaling pathway|
|nuclear envelope|
|positive regulation of DNA metabolic process|
|regulation of canonical Wnt signaling pathway|
|protein polyubiquitination|
|regulation of developmental growth|
|enzyme binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|negative regulation of organelle organization|
|developmental growth|
|growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of growth|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|protein localization to organelle|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|cell-cell signaling|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|negative regulation of nucleobase-containing compound metabolic process|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.82|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.87|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.89|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.96|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.14|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|4.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12902
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNKS2 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>