======= TNNI3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNNI3
  * **<color #00a2e8>Official Name</color>**: troponin I3, cardiac type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7137|7137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19429|P19429]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNNI3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNNI3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191044|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of systemic arterial blood pressure by ischemic conditions|
|troponin C binding|
|cardiac Troponin complex|
|troponin T binding|
|cardiac myofibril|
|troponin complex|
|nervous system process involved in regulation of systemic arterial blood pressure|
|calcium channel inhibitor activity|
|negative regulation of ATPase activity|
|regulation of cardiac muscle contraction by calcium ion signaling|
|skeletal muscle contraction|
|actin-myosin filament sliding|
|muscle filament sliding|
|multicellular organismal movement|
|musculoskeletal movement|
|ventricular cardiac muscle tissue morphogenesis|
|sarcomere|
|ventricular cardiac muscle tissue development|
|regulation of smooth muscle contraction|
|calcium-dependent protein binding|
|vasculogenesis|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|regulation of ATPase activity|
|heart contraction|
|muscle organ morphogenesis|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|regulation of systemic arterial blood pressure|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|calcium-mediated signaling|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|regulation of blood pressure|
|actin filament binding|
|regulation of muscle system process|
|regulation of heart contraction|
|protein domain specific binding|
|heart morphogenesis|
|muscle contraction|
|actin binding|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|second-messenger-mediated signaling|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|blood vessel development|
|divalent inorganic cation homeostasis|
|vasculature development|
|cardiovascular system development|
|heart development|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|negative regulation of catalytic activity|
|tube development|
|circulatory system development|
|cellular homeostasis|
|animal organ morphogenesis|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|nervous system process|
|movement of cell or subcellular component|
|homeostatic process|
|intracellular signal transduction|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.36|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.94|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.84|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.82|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.72|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.83|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7899
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNNI3 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>