======= TNP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNP1
  * **<color #00a2e8>Official Name</color>**: transition protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7141|7141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09430|P09430]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190231|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. {ECO:0000250|UniProtKB:P10856}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fertilization, exchange of chromosomal proteins|
|sperm chromatin decondensation|
|male pronucleus assembly|
|spermatid nucleus elongation|
|single strand break repair|
|spermatogenesis, exchange of chromosomal proteins|
|sperm chromatin condensation|
|nuclear nucleosome|
|male germ cell nucleus|
|nucleosome disassembly|
|chromatin disassembly|
|protein-DNA complex disassembly|
|spermatid nucleus differentiation|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|histone exchange|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|regulation of protein processing|
|nucleosome|
|regulation of protein maturation|
|chromatin organization involved in regulation of transcription|
|flagellated sperm motility|
|sperm motility|
|ATP-dependent chromatin remodeling|
|negative regulation of gene expression, epigenetic|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|nucleus organization|
|single fertilization|
|spermatid development|
|gene silencing|
|chromatin assembly or disassembly|
|spermatid differentiation|
|nucleosome organization|
|chromatin remodeling|
|fertilization|
|DNA packaging|
|regulation of gene expression, epigenetic|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|germ cell development|
|DNA conformation change|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of proteolysis|
|cellular component disassembly|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|chromatin organization|
|regulation of proteolysis|
|DNA metabolic process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|chromosome organization|
|cell motility|
|localization of cell|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|positive regulation of cellular protein metabolic process|
|cell development|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.91|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.74|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.71|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.71|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.76|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.82|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.83|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.85|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.88|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.95|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.08|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17525
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNP1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>