======= TNPO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNPO1
  * **<color #00a2e8>Official Name</color>**: transportin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3842|3842]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92973|Q92973]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNPO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNPO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602901|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19 (By similarity). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear import signal receptor activity|
|nuclear localization sequence binding|
|Ran GTPase binding|
|intraciliary transport involved in cilium assembly|
|intraciliary transport|
|microtubule-based protein transport|
|protein transport along microtubule|
|protein import into nucleus|
|import into nucleus|
|protein import|
|transport along microtubule|
|protein localization to nucleus|
|cytoskeleton-dependent intracellular transport|
|regulation of mRNA stability|
|microtubule-based transport|
|regulation of RNA stability|
|cilium|
|regulation of mRNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|microtubule-based movement|
|regulation of mRNA metabolic process|
|cilium assembly|
|cilium organization|
|establishment of protein localization to organelle|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|posttranscriptional regulation of gene expression|
|microtubule-based process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|intracellular protein transport|
|regulation of catabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.53|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.34|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.17|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.91|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.89|
|[[:results:exp539|42°C R08 exp539]]|-1.87|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.85|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.84|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.82|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.79|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.79|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.71|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.75|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.75|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.76|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.81|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.84|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.84|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.86|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.89|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.91|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.94|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.02|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.2|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.21|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.23|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.31|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.44|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.66|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.7|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.05|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.26|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|3.3|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.35|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|3.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:g3bp1|G3BP1]]|0.451|
|[[:human genes:r:ranbp1|RANBP1]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2067
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNPO1 Expression in NALM6 Cells: 8.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>