======= TOMM40 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOMM40
  * **<color #00a2e8>Official Name</color>**: translocase of outer mitochondrial membrane 40
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10452|10452]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96008|O96008]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOMM40&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOMM40|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Channel-forming protein essential for import of protein precursors into mitochondria. {ECO:0000269|PubMed:15644312}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Porin 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|porin activity|
|mitochondrial outer membrane translocase complex|
|pore complex|
|protein transmembrane transporter activity|
|protein import into mitochondrial matrix|
|integral component of mitochondrial outer membrane|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|protein import|
|macroautophagy|
|mitochondrial outer membrane|
|mitochondrial transport|
|process utilizing autophagic mechanism|
|autophagy|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.92|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.71|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.7|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.76|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.8|
|[[:results:exp539|42°C R08 exp539]]|1.86|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.98|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps34|MRPS34]]|0.516|
|[[:human genes:m:mrpl23|MRPL23]]|0.515|
|[[:human genes:t:timm8b|TIMM8B]]|0.513|
|[[:human genes:m:mrps16|MRPS16]]|0.506|
|[[:human genes:y:yars2|YARS2]]|0.494|
|[[:human genes:t:tomm20|TOMM20]]|0.49|
|[[:human genes:m:mrp63|MRP63]]|0.482|
|[[:human genes:r:rbfa|RBFA]]|0.482|
|[[:human genes:c:cox16|COX16]]|0.481|
|[[:human genes:h:hars|HARS]]|0.478|
|[[:human genes:s:sars2|SARS2]]|0.476|
|[[:human genes:g:gfm1|GFM1]]|0.468|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.464|
|[[:human genes:h:hccs|HCCS]]|0.464|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.464|
|[[:human genes:m:mrps5|MRPS5]]|0.461|
|[[:human genes:c:c12orf65|C12orf65]]|0.46|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.457|
|[[:human genes:t:tufm|TUFM]]|0.456|
|[[:human genes:m:mrpl21|MRPL21]]|0.45|
|[[:human genes:m:mrpl53|MRPL53]]|0.449|
|[[:human genes:p:pdss1|PDSS1]]|0.449|
|[[:human genes:s:slc25a26|SLC25A26]]|0.446|
|[[:human genes:p:pmm2|PMM2]]|0.444|
|[[:human genes:t:triap1|TRIAP1]]|0.443|
|[[:human genes:m:mrpl34|MRPL34]]|0.44|
|[[:human genes:m:mrps14|MRPS14]]|0.44|
|[[:human genes:b:bcs1l|BCS1L]]|0.438|
|[[:human genes:c:c17orf89|C17orf89]]|0.436|
|[[:human genes:m:mrps6|MRPS6]]|0.435|
|[[:human genes:g:gfm2|GFM2]]|0.435|
|[[:human genes:t:tars2|TARS2]]|0.434|
|[[:human genes:m:mtpap|MTPAP]]|0.433|
|[[:human genes:d:dap3|DAP3]]|0.432|
|[[:human genes:m:mrps18a|MRPS18A]]|0.432|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.429|
|[[:human genes:m:mrpl47|MRPL47]]|0.426|
|[[:human genes:t:trub2|TRUB2]]|0.425|
|[[:human genes:r:rpusd4|RPUSD4]]|0.425|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.424|
|[[:human genes:m:mrpl12|MRPL12]]|0.423|
|[[:human genes:s:selrc1|SELRC1]]|0.423|
|[[:human genes:c:chchd4|CHCHD4]]|0.423|
|[[:human genes:n:ndufa3|NDUFA3]]|0.422|
|[[:human genes:m:mtg2|MTG2]]|0.42|
|[[:human genes:m:mrpl45|MRPL45]]|0.42|
|[[:human genes:q:qrsl1|QRSL1]]|0.42|
|[[:human genes:d:dars2|DARS2]]|0.418|
|[[:human genes:u:uap1|UAP1]]|0.418|
|[[:human genes:m:mrps21|MRPS21]]|0.417|
|[[:human genes:e:ears2|EARS2]]|0.416|
|[[:human genes:m:mrps24|MRPS24]]|0.414|
|[[:human genes:m:mrps10|MRPS10]]|0.413|
|[[:human genes:s:sco2|SCO2]]|0.413|
|[[:human genes:c:cbfb|CBFB]]|0.411|
|[[:human genes:t:tomm22|TOMM22]]|0.41|
|[[:human genes:m:mrpl43|MRPL43]]|0.41|
|[[:human genes:s:srp14|SRP14]]|0.406|
|[[:human genes:c:coq3|COQ3]]|0.406|
|[[:human genes:v:vars2|VARS2]]|0.405|
|[[:human genes:m:mrps2|MRPS2]]|0.405|
|[[:human genes:m:mrpl55|MRPL55]]|0.404|
|[[:human genes:m:mrps33|MRPS33]]|0.403|
|[[:human genes:d:dpagt1|DPAGT1]]|0.402|
|[[:human genes:g:gfpt1|GFPT1]]|0.401|
|[[:human genes:f:fastkd5|FASTKD5]]|0.4|
|[[:human genes:c:c10orf2|C10orf2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 646/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|23/28|
|bone|23/26|
|breast|29/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|18/21|
|liver|19/20|
|lung|64/75|
|lymphocyte|16/16|
|ovary|20/26|
|pancreas|22/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 665
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOMM40 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>