======= TONSL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TONSL
  * **<color #00a2e8>Official Name</color>**: tonsoku like, DNA repair protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4796|4796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HA7|Q96HA7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TONSL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TONSL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604546|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:7738005}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FACT complex|
|nuclear replication fork|
|MCM complex|
|DNA replication factor A complex|
|cytoplasmic sequestering of transcription factor|
|cytoplasmic sequestering of protein|
|replication fork processing|
|DNA-dependent DNA replication maintenance of fidelity|
|double-strand break repair via homologous recombination|
|recombinational repair|
|maintenance of protein location|
|DNA-dependent DNA replication|
|histone binding|
|negative regulation of DNA-binding transcription factor activity|
|maintenance of location|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|transcription corepressor activity|
|nuclear body|
|regulation of DNA-binding transcription factor activity|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of molecular function|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.7|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.73|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.75|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.9|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.512|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.505|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.472|
|[[:human genes:s:supt5h|SUPT5H]]|0.459|
|[[:human genes:p:polr2j3|POLR2J3]]|0.453|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.45|
|[[:human genes:s:stil|STIL]]|0.438|
|[[:human genes:r:rfxank|RFXANK]]|0.437|
|[[:human genes:p:psmb4|PSMB4]]|0.434|
|[[:human genes:r:rrp7a|RRP7A]]|0.433|
|[[:human genes:m:mms22l|MMS22L]]|0.428|
|[[:human genes:t:tfip11|TFIP11]]|0.426|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.426|
|[[:human genes:i:itga2b|ITGA2B]]|0.424|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.423|
|[[:human genes:c:cacna1a|CACNA1A]]|0.421|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.42|
|[[:human genes:t:twistnb|TWISTNB]]|0.42|
|[[:human genes:c:ccna2|CCNA2]]|0.419|
|[[:human genes:v:vasn|VASN]]|0.418|
|[[:human genes:c:cbwd3|CBWD3]]|0.417|
|[[:human genes:p:psmb2|PSMB2]]|0.417|
|[[:human genes:a:ankle1|ANKLE1]]|0.416|
|[[:human genes:x:xab2|XAB2]]|0.415|
|[[:human genes:c:chd4|CHD4]]|0.413|
|[[:human genes:r:rrm1|RRM1]]|0.413|
|[[:human genes:c:copb2|COPB2]]|0.411|
|[[:human genes:g:gprin2|GPRIN2]]|0.406|
|[[:human genes:c:cbwd5|CBWD5]]|0.405|
|[[:human genes:s:slc4a1|SLC4A1]]|0.404|
|[[:human genes:c:cdc45|CDC45]]|0.404|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.401|
|[[:human genes:s:sart1|SART1]]|0.401|
|[[:human genes:c:chaf1a|CHAF1A]]|0.4|
|[[:human genes:n:npipb5|NPIPB5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 700/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|26/28|
|bone|25/25|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|14/14|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 173
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TONSL Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>