======= TOPBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOPBP1
  * **<color #00a2e8>Official Name</color>**: DNA topoisomerase II binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11073|11073]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92547|Q92547]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOPBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOPBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). {ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRCT|
|PTCB-BRCT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic DNA replication checkpoint|
|male germ cell nucleus|
|DNA replication checkpoint|
|mitotic G2/M transition checkpoint|
|condensed nuclear chromosome|
|negative regulation of G2/M transition of mitotic cell cycle|
|PML body|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|spindle pole|
|chromosome|
|DNA integrity checkpoint|
|response to ionizing radiation|
|mitotic cell cycle checkpoint|
|microtubule organizing center|
|regulation of signal transduction by p53 class mediator|
|protein C-terminus binding|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|DNA replication|
|actin cytoskeleton|
|negative regulation of cell cycle phase transition|
|nuclear body|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of mitotic cell cycle phase transition|
|response to radiation|
|regulation of cell cycle phase transition|
|DNA repair|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|identical protein binding|
|response to abiotic stimulus|
|regulation of cell cycle|
|cell cycle|
|DNA binding|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.38|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.95|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.75|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.72|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.76|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.81|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.04|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.1|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.478|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.443|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.442|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.441|
|[[:human genes:d:ddtl|DDTL]]|0.438|
|[[:human genes:s:smg1|SMG1]]|0.438|
|[[:human genes:v:vps54|VPS54]]|0.437|
|[[:human genes:n:nbpf10|NBPF10]]|0.428|
|[[:human genes:p:psmd11|PSMD11]]|0.423|
|[[:human genes:o:orc6|ORC6]]|0.423|
|[[:human genes:h:hap1|HAP1]]|0.423|
|[[:human genes:t:twistnb|TWISTNB]]|0.421|
|[[:human genes:c:chd4|CHD4]]|0.42|
|[[:human genes:o:or11h6|OR11H6]]|0.42|
|[[:human genes:n:ndc80|NDC80]]|0.416|
|[[:human genes:p:psma6|PSMA6]]|0.415|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.415|
|[[:human genes:c:cdc73|CDC73]]|0.414|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.412|
|[[:human genes:z:znf106|ZNF106]]|0.412|
|[[:human genes:t:tfip11|TFIP11]]|0.411|
|[[:human genes:c:copa|COPA]]|0.41|
|[[:human genes:a:atxn1|ATXN1]]|0.405|
|[[:human genes:p:pcf11|PCF11]]|0.404|
|[[:human genes:c:c14orf93|C14orf93]]|0.404|
|[[:human genes:c:cbwd3|CBWD3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 304/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|5/28|
|bone|14/26|
|breast|22/33|
|central nervous system|21/56|
|cervix|1/4|
|colorectal|9/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|11/21|
|liver|12/20|
|lung|30/75|
|lymphocyte|5/16|
|ovary|17/26|
|pancreas|7/24|
|peripheral nervous system|8/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|8/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 930
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOPBP1 Expression in NALM6 Cells: 7.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>