======= TOPORS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOPORS
  * **<color #00a2e8>Official Name</color>**: TOP1 binding arginine/serine rich protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10210|10210]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS56|Q9NS56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOPORS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOPORS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609507|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA topoisomerase binding|
|retinal rod cell development|
|photoreceptor cell outer segment organization|
|retinal cone cell differentiation|
|retinal cone cell development|
|gamma-tubulin complex|
|SUMO transferase activity|
|camera-type eye photoreceptor cell differentiation|
|cytoplasmic dynein complex|
|maintenance of protein location in nucleus|
|retina layer formation|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|positive regulation of ubiquitin-protein transferase activity|
|eye photoreceptor cell development|
|maintenance of protein localization in organelle|
|photoreceptor connecting cilium|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|retina morphogenesis in camera-type eye|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of ubiquitin-protein transferase activity|
|protein K48-linked ubiquitination|
|neural retina development|
|photoreceptor cell differentiation|
|protein monoubiquitination|
|protein sumoylation|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|maintenance of protein location in cell|
|maintenance of location in cell|
|PML body|
|ubiquitin ligase complex|
|maintenance of protein location|
|camera-type eye morphogenesis|
|positive regulation of protein ubiquitination|
|signal transduction by p53 class mediator|
|spindle pole|
|positive regulation of protein modification by small protein conjugation or removal|
|ciliary basal body|
|retina development in camera-type eye|
|centriole|
|antigen binding|
|eye morphogenesis|
|intrinsic apoptotic signaling pathway|
|midbody|
|protein localization to nucleus|
|maintenance of location|
|regulation of protein ubiquitination|
|ubiquitin protein ligase activity|
|regulation of protein modification by small protein conjugation or removal|
|ubiquitin-protein transferase activity|
|sensory organ morphogenesis|
|apoptotic signaling pathway|
|protein polyubiquitination|
|camera-type eye development|
|peptidyl-lysine modification|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|eye development|
|visual system development|
|sensory system development|
|nuclear speck|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|sensory organ development|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|protein catabolic process|
|protein ubiquitination|
|protein localization to organelle|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|neuron development|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|animal organ morphogenesis|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|neuron differentiation|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|proteolysis|
|organic cyclic compound biosynthetic process|
|positive regulation of catalytic activity|
|DNA binding|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.465|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13364
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOPORS Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>