======= TPM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPM1
  * **<color #00a2e8>Official Name</color>**: tropomyosin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7168|7168]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09493|P09493]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tropomyosin|
|Tropomyosin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of heart rate by epinephrine|
|positive regulation of heart rate by epinephrine-norepinephrine|
|muscle thin filament tropomyosin|
|regulation of heart rate by chemical signal|
|negative regulation of vascular associated smooth muscle cell migration|
|positive regulation of blood pressure by epinephrine-norepinephrine|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|bleb|
|negative regulation of vascular smooth muscle cell proliferation|
|negative regulation of smooth muscle cell migration|
|regulation of vascular associated smooth muscle cell migration|
|positive regulation of heart rate|
|ruffle organization|
|positive regulation of blood pressure|
|actin-myosin filament sliding|
|positive regulation of heart contraction|
|muscle filament sliding|
|negative regulation of smooth muscle cell proliferation|
|sarcomere organization|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|structural constituent of muscle|
|ventricular cardiac muscle tissue morphogenesis|
|sarcomere|
|regulation of vascular smooth muscle cell proliferation|
|positive regulation of stress fiber assembly|
|ventricular cardiac muscle tissue development|
|positive regulation of ATPase activity|
|regulation of smooth muscle cell migration|
|positive regulation of actin filament bundle assembly|
|myofibril assembly|
|stress fiber|
|cardiac muscle tissue morphogenesis|
|positive regulation of blood circulation|
|cardiac ventricle morphogenesis|
|cytoskeletal protein binding|
|cardiac muscle contraction|
|regulation of stress fiber assembly|
|muscle tissue morphogenesis|
|actin filament|
|regulation of ATPase activity|
|heart contraction|
|muscle organ morphogenesis|
|regulation of actomyosin structure organization|
|actin-mediated cell contraction|
|regulation of actin filament bundle assembly|
|regulation of systemic arterial blood pressure|
|ruffle membrane|
|regulation of heart rate|
|heart process|
|structural constituent of cytoskeleton|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|cellular response to reactive oxygen species|
|regulation of smooth muscle cell proliferation|
|striated muscle cell development|
|muscle cell development|
|regulation of cell shape|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|regulation of blood pressure|
|response to reactive oxygen species|
|positive regulation of supramolecular fiber organization|
|striated muscle cell differentiation|
|actin filament binding|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|regulation of muscle system process|
|actin filament organization|
|cellular response to oxidative stress|
|regulation of heart contraction|
|muscle cell differentiation|
|heart morphogenesis|
|muscle contraction|
|negative regulation of cell migration|
|regulation of actin filament organization|
|actin binding|
|negative regulation of cell motility|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|in utero embryonic development|
|response to oxidative stress|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|positive regulation of cell adhesion|
|supramolecular fiber organization|
|muscle structure development|
|wound healing|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|heart development|
|regulation of cytoskeleton organization|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|regulation of system process|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|organelle assembly|
|positive regulation of hydrolase activity|
|cellular component morphogenesis|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|cell development|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.7|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12004
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPM1 Expression in NALM6 Cells: 4.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>