======= TRA2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRA2A
  * **<color #00a2e8>Official Name</color>**: transformer 2 alpha homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29896|29896]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13595|Q13595]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRA2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRA2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602718|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mRNA splicing, via spliceosome|
|positive regulation of mRNA processing|
|positive regulation of RNA splicing|
|positive regulation of mRNA metabolic process|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|ribonucleoprotein complex|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|mRNA processing|
|intracellular membrane-bounded organelle|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.08|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.84|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.7|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.72|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.75|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.75|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.78|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.88|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.96|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.07|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.2|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.22|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.4|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.54|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.521|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRA2A Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>