======= TRAF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAF6
  * **<color #00a2e8>Official Name</color>**: TNF receptor associated factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7189|7189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4K3|Q9Y4K3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602355|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:12140561, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:17135271, ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:18347055, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:19465916, ECO:0000269|PubMed:19675569, ECO:0000269|PubMed:19713527, ECO:0000269|PubMed:8837778}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|MATH|
|zf-TRAF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of interleukin-12 biosynthetic process|
|positive regulation of lipopolysaccharide-mediated signaling pathway|
|regulation of interleukin-12 biosynthetic process|
|protein kinase B binding|
|CD40 receptor complex|
|thioesterase binding|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of interleukin-6 biosynthetic process|
|toll-like receptor 9 signaling pathway|
|activation of NF-kappaB-inducing kinase activity|
|mitogen-activated protein kinase kinase kinase binding|
|myeloid dendritic cell differentiation|
|positive regulation of T cell cytokine production|
|regulation of immunoglobulin secretion|
|regulation of leukocyte adhesion to vascular endothelial cell|
|T-helper 1 type immune response|
|membrane protein intracellular domain proteolysis|
|myeloid dendritic cell activation|
|regulation of interleukin-6 biosynthetic process|
|bone resorption|
|regulation of lipopolysaccharide-mediated signaling pathway|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of osteoclast differentiation|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|positive regulation of interleukin-2 production|
|tumor necrosis factor receptor binding|
|regulation of T cell cytokine production|
|dendritic cell differentiation|
|MyD88-dependent toll-like receptor signaling pathway|
|ubiquitin conjugating enzyme binding|
|cytoplasmic pattern recognition receptor signaling pathway|
|positive regulation of interleukin-12 production|
|membrane protein proteolysis|
|protein K63-linked ubiquitination|
|osteoclast differentiation|
|bone remodeling|
|positive regulation of T cell mediated immunity|
|regulation of transcription regulatory region DNA binding|
|cytoplasmic side of plasma membrane|
|regulation of interleukin-2 production|
|positive regulation of cytokine production involved in immune response|
|regulation of interleukin-12 production|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of DNA binding|
|regulation of immunoglobulin production|
|regulation of osteoclast differentiation|
|protein autoubiquitination|
|positive regulation of cytokine biosynthetic process|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of T cell mediated immunity|
|positive regulation of JUN kinase activity|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|lipid droplet|
|JNK cascade|
|odontogenesis of dentin-containing tooth|
|regulation of cytokine production involved in immune response|
|positive regulation of smooth muscle cell proliferation|
|regulation of JUN kinase activity|
|neural tube closure|
|positive regulation of myeloid cell differentiation|
|tube closure|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|interleukin-1-mediated signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|primary neural tube formation|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|toll-like receptor signaling pathway|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|antigen processing and presentation of peptide antigen via MHC class II|
|tissue remodeling|
|stress-activated MAPK cascade|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|regulation of cytokine biosynthetic process|
|neural tube formation|
|protein N-terminus binding|
|regulation of NIK/NF-kappaB signaling|
|myeloid leukocyte differentiation|
|histone deacetylase binding|
|stimulatory C-type lectin receptor signaling pathway|
|regulation of myeloid leukocyte differentiation|
|innate immune response activating cell surface receptor signaling pathway|
|positive regulation of protein ubiquitination|
|odontogenesis|
|embryonic epithelial tube formation|
|regulation of DNA binding|
|pattern recognition receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|epithelial tube formation|
|positive regulation of leukocyte mediated immunity|
|regulation of smooth muscle cell proliferation|
|positive regulation of protein modification by small protein conjugation or removal|
|cell cortex|
|positive regulation of leukocyte proliferation|
|positive regulation of JNK cascade|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|stress-activated protein kinase signaling cascade|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|morphogenesis of embryonic epithelium|
|positive regulation of leukocyte differentiation|
|tube formation|
|regulation of lymphocyte mediated immunity|
|positive regulation of NF-kappaB transcription factor activity|
|activation of MAPK activity|
|regulation of T cell proliferation|
|neural tube development|
|regulation of adaptive immune response|
|intracellular receptor signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of binding|
|antigen processing and presentation of exogenous antigen|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to lipopolysaccharide|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|antigen processing and presentation of peptide antigen|
|tissue homeostasis|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|regulation of protein ubiquitination|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|endosome membrane|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|antigen processing and presentation|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|ubiquitin protein ligase activity|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|regulation of protein modification by small protein conjugation or removal|
|regulation of stress-activated MAPK cascade|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|Fc receptor signaling pathway|
|ubiquitin-protein transferase activity|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of MAP kinase activity|
|ossification|
|positive regulation of DNA-binding transcription factor activity|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|protein deubiquitination|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|protein modification by small protein removal|
|protein polyubiquitination|
|epithelial tube morphogenesis|
|response to lipopolysaccharide|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|leukocyte differentiation|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|in utero embryonic development|
|regulation of binding|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|protein kinase binding|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|hemopoiesis|
|immune response-activating signal transduction|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|protein-containing complex|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|activation of immune response|
|chordate embryonic development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|protein ubiquitination|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of secretion|
|zinc ion binding|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|leukocyte activation|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|regulation of response to external stimulus|
|response to cytokine|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.7|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAF6 Expression in NALM6 Cells: 4.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>