======= TRAPPC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC3
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27095|27095]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43617|O43617]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610955|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAPP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cis-Golgi network membrane|
|TRAPP complex|
|intra-Golgi vesicle-mediated transport|
|Rab guanyl-nucleotide exchange factor activity|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|organelle localization|
|Golgi membrane|
|membrane organization|
|Golgi apparatus|
|endoplasmic reticulum|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.27|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.06|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.05|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.92|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.91|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.9|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.89|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.88|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.87|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.85|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.81|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.76|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.75|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.74|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.7|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.545|
|[[:human genes:r:rabggtb|RABGGTB]]|0.414|
|[[:human genes:n:nsmce1|NSMCE1]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 721/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|25/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2004
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC3 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>