======= TRIM21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM21
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6737|6737]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19474|P19474]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139). {ECO:0000269|PubMed:16297862, ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:16880511, ECO:0000269|PubMed:18022694, ECO:0000269|PubMed:18361920, ECO:0000269|PubMed:18641315, ECO:0000269|PubMed:18845142, ECO:0000269|PubMed:19675099, ECO:0000269|PubMed:26347139}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|zf-C3HC4|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein deubiquitination|
|positive regulation of viral entry into host cell|
|regulation of protein deubiquitination|
|negative regulation of viral release from host cell|
|negative regulation of viral transcription|
|regulation of viral entry into host cell|
|regulation of viral release from host cell|
|protein destabilization|
|protein trimerization|
|positive regulation of viral life cycle|
|protein monoubiquitination|
|SCF ubiquitin ligase complex|
|regulation of viral transcription|
|protein autoubiquitination|
|autophagosome|
|interferon-gamma-mediated signaling pathway|
|negative regulation of viral life cycle|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of protein modification by small protein conjugation or removal|
|P-body|
|negative regulation of viral process|
|positive regulation of viral process|
|positive regulation of autophagy|
|regulation of type I interferon production|
|regulation of viral life cycle|
|ribonucleoprotein complex|
|negative regulation of DNA-binding transcription factor activity|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of protein modification by small protein conjugation or removal|
|ubiquitin-protein transferase activity|
|cytoplasmic vesicle|
|positive regulation of DNA-binding transcription factor activity|
|regulation of protein stability|
|protein polyubiquitination|
|negative regulation of locomotion|
|regulation of autophagy|
|negative regulation of proteolysis|
|positive regulation of cellular catabolic process|
|positive regulation of cell cycle|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|negative regulation of protein modification process|
|cytokine-mediated signaling pathway|
|protein ubiquitination|
|regulation of cytokine production|
|regulation of proteolysis|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|zinc ion binding|
|defense response to other organism|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cell cycle|
|RNA binding|
|DNA binding|
|protein-containing complex assembly|
|positive regulation of molecular function|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7617
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM21 Expression in NALM6 Cells: 3.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>