======= TRIO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIO
  * **<color #00a2e8>Official Name</color>**: trio Rho guanine nucleotide exchange factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7204|7204]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75962|O75962]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601893|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:8643598}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|RhoGEF|
|Pkinase|
|SH3 1|
|I-set|
|Spectrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transmembrane receptor protein tyrosine phosphatase signaling pathway|
|negative regulation of fat cell differentiation|
|Rho guanyl-nucleotide exchange factor activity|
|guanyl-nucleotide exchange factor activity|
|regulation of fat cell differentiation|
|regulation of Rho protein signal transduction|
|regulation of Ras protein signal transduction|
|axon guidance|
|neuron projection guidance|
|regulation of small GTPase mediated signal transduction|
|protein serine/threonine kinase activity|
|axonogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|neuron projection development|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|negative regulation of developmental process|
|protein phosphorylation|
|central nervous system development|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of cell death|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.94|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.82|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.81|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9724
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIO Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>