======= TRMT10A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRMT10A
  * **<color #00a2e8>Official Name</color>**: tRNA methyltransferase 10A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93587|93587]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TBZ6|Q8TBZ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRMT10A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRMT10A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616013|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)- methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)- methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA m1G MT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA (guanine(9)-N(1))-methyltransferase activity|
|tRNA (guanine-N1-)-methyltransferase activity|
|mitochondrial tRNA processing|
|mitochondrial RNA processing|
|tRNA methylation|
|mitochondrial RNA metabolic process|
|tRNA binding|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|mitochondrial gene expression|
|RNA modification|
|tRNA metabolic process|
|actin cytoskeleton|
|macromolecule methylation|
|methylation|
|ncRNA processing|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.62|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.32|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-2.32|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.13|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.09|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-2.06|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.06|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.98|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.94|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.85|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.84|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.77|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.77|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.76|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.74|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.75|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.75|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.76|
|[[:results:exp539|42°C R08 exp539]]|1.8|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.81|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.82|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.82|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.85|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.85|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.86|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.87|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.94|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.95|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.04|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.21|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.24|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.27|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.3|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.42|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.44|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.58|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.59|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.6|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|3.09|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.12|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.62|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|3.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.586|
|[[:human genes:t:trmt61a|TRMT61A]]|0.552|
|[[:human genes:p:pmm2|PMM2]]|0.549|
|[[:human genes:d:dohh|DOHH]]|0.547|
|[[:human genes:t:triap1|TRIAP1]]|0.545|
|[[:human genes:a:alg6|ALG6]]|0.543|
|[[:human genes:a:alg1|ALG1]]|0.541|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.531|
|[[:human genes:d:dpagt1|DPAGT1]]|0.527|
|[[:human genes:r:rptor|RPTOR]]|0.524|
|[[:human genes:c:cbfb|CBFB]]|0.521|
|[[:human genes:r:romo1|ROMO1]]|0.521|
|[[:human genes:t:timm13|TIMM13]]|0.514|
|[[:human genes:a:alg13|ALG13]]|0.503|
|[[:human genes:e:eef1e1|EEF1E1]]|0.502|
|[[:human genes:s:sec62|SEC62]]|0.501|
|[[:human genes:r:rnmt|RNMT]]|0.499|
|[[:human genes:t:tmem41b|TMEM41B]]|0.496|
|[[:human genes:t:taz|TAZ]]|0.491|
|[[:human genes:d:dnlz|DNLZ]]|0.484|
|[[:human genes:g:gfpt1|GFPT1]]|0.484|
|[[:human genes:c:crls1|CRLS1]]|0.484|
|[[:human genes:a:atxn10|ATXN10]]|0.483|
|[[:human genes:y:yars2|YARS2]]|0.482|
|[[:human genes:a:alg5|ALG5]]|0.481|
|[[:human genes:p:pdap1|PDAP1]]|0.478|
|[[:human genes:c:c17orf89|C17orf89]]|0.477|
|[[:human genes:s:srp14|SRP14]]|0.476|
|[[:human genes:n:nsd1|NSD1]]|0.476|
|[[:human genes:k:kdsr|KDSR]]|0.475|
|[[:human genes:p:pdss1|PDSS1]]|0.474|
|[[:human genes:s:slc25a26|SLC25A26]]|0.474|
|[[:human genes:s:ssb|SSB]]|0.473|
|[[:human genes:o:opa1|OPA1]]|0.469|
|[[:human genes:o:oraov1|ORAOV1]]|0.466|
|[[:human genes:m:mrps5|MRPS5]]|0.465|
|[[:human genes:d:dhrsx|DHRSX]]|0.464|
|[[:human genes:m:mbtps2|MBTPS2]]|0.461|
|[[:human genes:r:rpia|RPIA]]|0.461|
|[[:human genes:p:ppcs|PPCS]]|0.46|
|[[:human genes:d:dnajc3|DNAJC3]]|0.46|
|[[:human genes:l:lsm10|LSM10]]|0.456|
|[[:human genes:m:mrpl23|MRPL23]]|0.456|
|[[:human genes:v:vezt|VEZT]]|0.456|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.455|
|[[:human genes:m:maml1|MAML1]]|0.454|
|[[:human genes:g:gfm2|GFM2]]|0.454|
|[[:human genes:u:urm1|URM1]]|0.453|
|[[:human genes:c:cep57|CEP57]]|0.453|
|[[:human genes:u:uap1|UAP1]]|0.452|
|[[:human genes:u:ube2g2|UBE2G2]]|0.451|
|[[:human genes:h:haus8|HAUS8]]|0.451|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.45|
|[[:human genes:s:ssbp2|SSBP2]]|0.449|
|[[:human genes:u:uhrf1|UHRF1]]|0.447|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.444|
|[[:human genes:w:wdr59|WDR59]]|0.444|
|[[:human genes:t:tmem126b|TMEM126B]]|0.443|
|[[:human genes:g:gatc|GATC]]|0.443|
|[[:human genes:s:sox7|SOX7]]|0.443|
|[[:human genes:u:utp23|UTP23]]|0.44|
|[[:human genes:a:atp5o|ATP5O]]|0.44|
|[[:human genes:m:med16|MED16]]|0.44|
|[[:human genes:r:rtcb|RTCB]]|0.439|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.439|
|[[:human genes:b:bap1|BAP1]]|0.437|
|[[:human genes:t:tpk1|TPK1]]|0.437|
|[[:human genes:l:lmo2|LMO2]]|0.436|
|[[:human genes:w:wdr24|WDR24]]|0.434|
|[[:human genes:e:eif1ax|EIF1AX]]|0.434|
|[[:human genes:x:xpo6|XPO6]]|0.434|
|[[:human genes:p:pitrm1|PITRM1]]|0.433|
|[[:human genes:s:srd5a3|SRD5A3]]|0.433|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.432|
|[[:human genes:m:med23|MED23]]|0.432|
|[[:human genes:m:med4|MED4]]|0.432|
|[[:human genes:p:parl|PARL]]|0.431|
|[[:human genes:r:rft1|RFT1]]|0.431|
|[[:human genes:l:lsm11|LSM11]]|0.429|
|[[:human genes:u:uba5|UBA5]]|0.429|
|[[:human genes:t:ttc4|TTC4]]|0.428|
|[[:human genes:e:exoc4|EXOC4]]|0.428|
|[[:human genes:r:rpp21|RPP21]]|0.427|
|[[:human genes:a:actc1|ACTC1]]|0.426|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.426|
|[[:human genes:z:zzz3|ZZZ3]]|0.425|
|[[:human genes:a:atp5j|ATP5J]]|0.425|
|[[:human genes:t:trnt1|TRNT1]]|0.424|
|[[:human genes:m:minos1|MINOS1]]|0.424|
|[[:human genes:d:dolk|DOLK]]|0.424|
|[[:human genes:r:rpe|RPE]]|0.423|
|[[:human genes:g:gmppb|GMPPB]]|0.423|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.423|
|[[:human genes:t:tefm|TEFM]]|0.422|
|[[:human genes:v:vps41|VPS41]]|0.422|
|[[:human genes:a:atp5d|ATP5D]]|0.421|
|[[:human genes:d:dars2|DARS2]]|0.421|
|[[:human genes:z:zfx|ZFX]]|0.42|
|[[:human genes:m:mrps14|MRPS14]]|0.42|
|[[:human genes:t:tmem242|TMEM242]]|0.418|
|[[:human genes:r:rpusd4|RPUSD4]]|0.418|
|[[:human genes:a:asxl2|ASXL2]]|0.417|
|[[:human genes:m:mlst8|MLST8]]|0.417|
|[[:human genes:t:txnl4b|TXNL4B]]|0.417|
|[[:human genes:c:ccdc101|CCDC101]]|0.416|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.415|
|[[:human genes:b:bcs1l|BCS1L]]|0.415|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.414|
|[[:human genes:d:dhps|DHPS]]|0.414|
|[[:human genes:p:ppa2|PPA2]]|0.412|
|[[:human genes:a:alg8|ALG8]]|0.412|
|[[:human genes:d:dap3|DAP3]]|0.412|
|[[:human genes:c:c14orf2|C14orf2]]|0.412|
|[[:human genes:a:atp5b|ATP5B]]|0.411|
|[[:human genes:i:id3|ID3]]|0.411|
|[[:human genes:a:atp2a2|ATP2A2]]|0.411|
|[[:human genes:a:atp5a1|ATP5A1]]|0.409|
|[[:human genes:e:eif1|EIF1]]|0.408|
|[[:human genes:e:elp3|ELP3]]|0.407|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.407|
|[[:human genes:m:mrps16|MRPS16]]|0.407|
|[[:human genes:a:atp5h|ATP5H]]|0.406|
|[[:human genes:t:tmed10|TMED10]]|0.406|
|[[:human genes:f:fh|FH]]|0.405|
|[[:human genes:t:timm8b|TIMM8B]]|0.404|
|[[:human genes:f:fli1|FLI1]]|0.403|
|[[:human genes:t:trmt6|TRMT6]]|0.402|
|[[:human genes:v:vars2|VARS2]]|0.402|
|[[:human genes:a:adsl|ADSL]]|0.401|
|[[:human genes:m:mocs3|MOCS3]]|0.401|
|[[:human genes:t:trim33|TRIM33]]|0.4|
|[[:human genes:t:tbcb|TBCB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5002
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRMT10A Expression in NALM6 Cells: 2.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>