======= TRPA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPA1
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8989|8989]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75762|O75762]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins.  The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:25855297}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|temperature-gated cation channel activity|
|detection of chemical stimulus involved in sensory perception of pain|
|thermoception|
|stereocilium bundle|
|detection of mechanical stimulus involved in sensory perception of pain|
|calcium-release channel activity|
|channel activity|
|sensory perception of temperature stimulus|
|detection of mechanical stimulus involved in sensory perception|
|response to pain|
|detection of mechanical stimulus|
|response to cold|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|calcium ion transmembrane import into cytosol|
|multicellular organismal response to stress|
|calcium ion transport into cytosol|
|sensory perception of pain|
|cytosolic calcium ion transport|
|protein homotetramerization|
|response to hydrogen peroxide|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of sequestering of calcium ion|
|protein tetramerization|
|sensory perception of mechanical stimulus|
|response to temperature stimulus|
|response to reactive oxygen species|
|calcium ion transmembrane transport|
|response to mechanical stimulus|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|divalent inorganic cation transport|
|response to antibiotic|
|regulation of cytosolic calcium ion concentration|
|protein homooligomerization|
|response to oxidative stress|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|detection of chemical stimulus involved in sensory perception|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|protein complex oligomerization|
|detection of chemical stimulus|
|response to inorganic substance|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|detection of stimulus|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|response to organic cyclic compound|
|ion transmembrane transport|
|sensory perception|
|response to drug|
|identical protein binding|
|chemical homeostasis|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.91|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.85|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.98|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15543
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPA1 Expression in NALM6 Cells: -2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>