======= TSPAN10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSPAN10
  * **<color #00a2e8>Official Name</color>**: tetraspanin 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83882|83882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1Z9|Q9H1Z9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSPAN10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSPAN10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates maturation of the transmembrane metalloprotease ADAM10. {ECO:0000250|UniProtKB:Q8VCF5}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tetraspannin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein maturation|
|enzyme binding|
|establishment of protein localization to organelle|
|protein localization to organelle|
|integral component of plasma membrane|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.24|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.17|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.96|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.88|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.81|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.72|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.78|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3610
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSPAN10 Expression in NALM6 Cells: 3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>