======= TSR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSR2
  * **<color #00a2e8>Official Name</color>**: TSR2 ribosome maturation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90121|90121]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969E8|Q969E8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in 20S pre-rRNA processing. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WGG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.7|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.7|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.73|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.83|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.83|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.84|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.84|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.85|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.97|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.18|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.32|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.45|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.89|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.92|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.647|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 693/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/26|
|bone|26/26|
|breast|30/30|
|central nervous system|49/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|18/18|
|liver|19/19|
|lung|72/72|
|lymphocyte|16/16|
|ovary|25/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|20/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 27
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSR2 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>