======= TTPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTPA
  * **<color #00a2e8>Official Name</color>**: alpha tocopherol transfer protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7274|7274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49638|P49638]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600415|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). {ECO:0000250, ECO:0000269|PubMed:7887897}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CRAL TRIO N|
|CRAL TRIO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipid transfer activity|
|negative regulation of establishment of blood-brain barrier|
|vitamin E binding|
|vitamin E metabolic process|
|regulation of establishment of blood-brain barrier|
|intermembrane lipid transfer|
|phosphatidylinositol-3,4-bisphosphate binding|
|fat-soluble vitamin metabolic process|
|vitamin transport|
|response to pH|
|intracellular pH reduction|
|pH reduction|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of intracellular pH|
|embryonic placenta development|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|vitamin metabolic process|
|late endosome|
|monovalent inorganic cation homeostasis|
|placenta development|
|response to nutrient|
|lipid transport|
|lipid localization|
|negative regulation of cell development|
|in utero embryonic development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|organic hydroxy compound metabolic process|
|response to nutrient levels|
|response to toxic substance|
|response to extracellular stimulus|
|cellular cation homeostasis|
|chordate embryonic development|
|cellular ion homeostasis|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|membrane organization|
|cellular homeostasis|
|regulation of cell development|
|negative regulation of developmental process|
|embryo development|
|negative regulation of cell death|
|chemical homeostasis|
|response to abiotic stimulus|
|lipid metabolic process|
|reproductive process|
|reproduction|
|homeostatic process|
|regulation of cell death|
|small molecule metabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14325
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTPA Expression in NALM6 Cells: 0.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>