======= TUB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUB
  * **<color #00a2e8>Official Name</color>**: TUB bipartite transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7275|7275]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50607|P50607]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601197|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:19837063}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tub|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intraciliary transport particle A binding|
|receptor localization to non-motile cilium|
|protein localization to photoreceptor outer segment|
|protein localization to ciliary membrane|
|protein localization to non-motile cilium|
|photoreceptor cell maintenance|
|protein localization to cilium|
|intraciliary transport|
|G protein-coupled receptor binding|
|microtubule-based protein transport|
|protein transport along microtubule|
|positive regulation of phagocytosis|
|retina homeostasis|
|regulation of phagocytosis|
|phagocytosis, recognition|
|retina development in camera-type eye|
|regulation of G protein-coupled receptor signaling pathway|
|sensory perception of sound|
|transport along microtubule|
|sensory perception of mechanical stimulus|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|tissue homeostasis|
|cilium|
|protein localization to cell periphery|
|cell recognition|
|protein-containing complex localization|
|protein-containing complex binding|
|microtubule-based movement|
|camera-type eye development|
|multicellular organismal homeostasis|
|phagocytosis|
|anatomical structure homeostasis|
|eye development|
|visual system development|
|sensory system development|
|cilium organization|
|protein localization to membrane|
|sensory organ development|
|regulation of vesicle-mediated transport|
|endocytosis|
|microtubule-based process|
|import into cell|
|protein localization to organelle|
|response to hormone|
|sensory perception|
|positive regulation of transport|
|intracellular protein transport|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16276
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUB Expression in NALM6 Cells: 0.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>