======= TUBD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBD1
  * **<color #00a2e8>Official Name</color>**: tubulin delta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51174|51174]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJT1|Q9UJT1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607344|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of smoothened signaling pathway|
|regulation of smoothened signaling pathway|
|structural constituent of cytoskeleton|
|centriole|
|cilium|
|microtubule|
|GTPase activity|
|GTP binding|
|microtubule cytoskeleton organization|
|microtubule-based process|
|mitotic cell cycle|
|cytoskeleton organization|
|cell projection organization|
|cell cycle|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.09|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.98|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.89|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.86|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.76|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.74|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.73|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.73|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.7|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.72|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.78|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.06|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.48|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|4.06|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|4.88|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf80|C14orf80]]|0.788|
|[[:human genes:c:c16orf59|C16orf59]]|0.715|
|[[:human genes:t:tube1|TUBE1]]|0.715|
|[[:human genes:c:casp2|CASP2]]|0.613|
|[[:human genes:c:cep120|CEP120]]|0.596|
|[[:human genes:c:cep44|CEP44]]|0.579|
|[[:human genes:p:pibf1|PIBF1]]|0.568|
|[[:human genes:c:c2cd3|C2CD3]]|0.568|
|[[:human genes:p:pidd|PIDD]]|0.563|
|[[:human genes:c:ccdc41|CCDC41]]|0.553|
|[[:human genes:c:cradd|CRADD]]|0.518|
|[[:human genes:o:odf2|ODF2]]|0.516|
|[[:human genes:b:bub3|BUB3]]|0.5|
|[[:human genes:c:cep78|CEP78]]|0.495|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.489|
|[[:human genes:f:fopnl|FOPNL]]|0.486|
|[[:human genes:a:ankrd26|ANKRD26]]|0.485|
|[[:human genes:e:elp3|ELP3]]|0.479|
|[[:human genes:o:ofd1|OFD1]]|0.474|
|[[:human genes:s:srp14|SRP14]]|0.473|
|[[:human genes:d:ddx42|DDX42]]|0.467|
|[[:human genes:g:gemin8|GEMIN8]]|0.467|
|[[:human genes:n:nin|NIN]]|0.462|
|[[:human genes:t:tsen54|TSEN54]]|0.456|
|[[:human genes:p:pmvk|PMVK]]|0.452|
|[[:human genes:n:n6amt1|N6AMT1]]|0.45|
|[[:human genes:r:rabggtb|RABGGTB]]|0.448|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.446|
|[[:human genes:u:urm1|URM1]]|0.445|
|[[:human genes:w:wdr1|WDR1]]|0.444|
|[[:human genes:t:tkt|TKT]]|0.444|
|[[:human genes:p:ppcdc|PPCDC]]|0.44|
|[[:human genes:g:gemin6|GEMIN6]]|0.438|
|[[:human genes:p:ptar1|PTAR1]]|0.434|
|[[:human genes:c:cenpa|CENPA]]|0.434|
|[[:human genes:t:thg1l|THG1L]]|0.431|
|[[:human genes:c:c15orf41|C15orf41]]|0.43|
|[[:human genes:d:ddx39a|DDX39A]]|0.43|
|[[:human genes:a:atic|ATIC]]|0.429|
|[[:human genes:l:lsm10|LSM10]]|0.421|
|[[:human genes:t:ten1|TEN1]]|0.42|
|[[:human genes:s:sclt1|SCLT1]]|0.42|
|[[:human genes:s:srp9|SRP9]]|0.417|
|[[:human genes:t:trmt61a|TRMT61A]]|0.417|
|[[:human genes:f:fkbpl|FKBPL]]|0.416|
|[[:human genes:a:atxn10|ATXN10]]|0.412|
|[[:human genes:p:ppp6c|PPP6C]]|0.411|
|[[:human genes:z:zcrb1|ZCRB1]]|0.41|
|[[:human genes:s:snapc5|SNAPC5]]|0.409|
|[[:human genes:h:hyls1|HYLS1]]|0.408|
|[[:human genes:r:rpia|RPIA]]|0.403|
|[[:human genes:c:cep76|CEP76]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1657
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBD1 Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>