======= TUBG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBG1
  * **<color #00a2e8>Official Name</color>**: tubulin gamma 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7283|7283]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23258|P23258]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191135|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Misat Myo SegII|
|Tubulin|
|Tubulin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polar microtubule|
|meiotic spindle organization|
|gamma-tubulin complex|
|microtubule nucleation|
|pericentriolar material|
|condensed nuclear chromosome|
|non-motile cilium|
|microtubule polymerization|
|cell leading edge|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule|
|cytoplasmic microtubule organization|
|apical part of cell|
|mitotic spindle organization|
|protein polymerization|
|ciliary basal body-plasma membrane docking|
|structural constituent of cytoskeleton|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|recycling endosome|
|spindle|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|ciliary basal body|
|sister chromatid segregation|
|centriole|
|mitotic nuclear division|
|spindle organization|
|meiotic cell cycle process|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|nuclear chromosome segregation|
|meiotic cell cycle|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|nuclear division|
|organelle fission|
|microtubule|
|GTPase activity|
|cilium assembly|
|cilium organization|
|GTP binding|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|identical protein binding|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.99|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.79|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.56|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.37|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.19|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.19|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.94|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.91|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.84|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.8|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.71|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 665/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|23/26|
|breast|27/33|
|central nervous system|53/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|19/20|
|lung|67/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|20/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1011
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBG1 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>