======= TUBGCP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBGCP5
  * **<color #00a2e8>Official Name</color>**: tubulin gamma complex associated protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114791|114791]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RT8|Q96RT8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBGCP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBGCP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608147|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spc97 Spc98|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|equatorial microtubule organizing center|
|microtubule nucleation by interphase microtubule organizing center|
|gamma-tubulin ring complex|
|microtubule nucleation by microtubule organizing center|
|microtubule minus-end binding|
|gamma-tubulin complex|
|microtubule nucleation|
|gamma-tubulin binding|
|microtubule polymerization|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule organization|
|protein polymerization|
|spindle assembly|
|spindle pole|
|spindle organization|
|meiotic cell cycle|
|microtubule binding|
|microtubule|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 482/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|18/28|
|bone|21/26|
|breast|22/33|
|central nervous system|41/56|
|cervix|2/4|
|colorectal|11/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|12/21|
|liver|16/20|
|lung|54/75|
|lymphocyte|13/16|
|ovary|17/26|
|pancreas|15/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|17/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2296
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBGCP5 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>