======= TWISTNB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TWISTNB
  * **<color #00a2e8>Official Name</color>**: TWIST neighbor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221830|221830]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3B726|Q3B726]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TWISTNB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TWISTNB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol Rpb7 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase I activity|
|RNA polymerase I complex|
|transcription elongation from RNA polymerase I promoter|
|termination of RNA polymerase I transcription|
|DNA-directed 5-3 RNA polymerase activity|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|positive regulation of gene expression, epigenetic|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to cytokine stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.76|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.579|
|[[:human genes:v:vasn|VASN]]|0.571|
|[[:human genes:c:cbwd3|CBWD3]]|0.571|
|[[:human genes:c:cbwd6|CBWD6]]|0.561|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.56|
|[[:human genes:k:kctd17|KCTD17]]|0.559|
|[[:human genes:p:psma6|PSMA6]]|0.557|
|[[:human genes:h:hap1|HAP1]]|0.549|
|[[:human genes:m:med17|MED17]]|0.548|
|[[:human genes:p:psmb4|PSMB4]]|0.547|
|[[:human genes:p:prim1|PRIM1]]|0.547|
|[[:human genes:c:cdc45|CDC45]]|0.543|
|[[:human genes:t:ticrr|TICRR]]|0.543|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.541|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.534|
|[[:human genes:c:cbwd5|CBWD5]]|0.532|
|[[:human genes:c:col2a1|COL2A1]]|0.524|
|[[:human genes:c:chd4|CHD4]]|0.524|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.523|
|[[:human genes:c:c14orf93|C14orf93]]|0.51|
|[[:human genes:n:nupl1|NUPL1]]|0.509|
|[[:human genes:c:cep192|CEP192]]|0.508|
|[[:human genes:r:rps7|RPS7]]|0.508|
|[[:human genes:t:tceb3c|TCEB3C]]|0.508|
|[[:human genes:g:gprin2|GPRIN2]]|0.506|
|[[:human genes:n:nbpf10|NBPF10]]|0.505|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.505|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.505|
|[[:human genes:r:rps2|RPS2]]|0.505|
|[[:human genes:d:dtl|DTL]]|0.505|
|[[:human genes:r:rpl9|RPL9]]|0.504|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.503|
|[[:human genes:o:or10g3|OR10G3]]|0.503|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.502|
|[[:human genes:i:ik|IK]]|0.501|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.501|
|[[:human genes:p:psmd1|PSMD1]]|0.5|
|[[:human genes:p:psmb1|PSMB1]]|0.499|
|[[:human genes:r:rfxank|RFXANK]]|0.499|
|[[:human genes:z:zfand5|ZFAND5]]|0.497|
|[[:human genes:n:npipb5|NPIPB5]]|0.497|
|[[:human genes:s:stil|STIL]]|0.496|
|[[:human genes:o:orc1|ORC1]]|0.496|
|[[:human genes:g:gar1|GAR1]]|0.496|
|[[:human genes:s:ssh2|SSH2]]|0.494|
|[[:human genes:p:psmb2|PSMB2]]|0.494|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.494|
|[[:human genes:u:upf1|UPF1]]|0.492|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.492|
|[[:human genes:d:ddtl|DDTL]]|0.492|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.492|
|[[:human genes:r:rps12|RPS12]]|0.491|
|[[:human genes:p:psmd2|PSMD2]]|0.49|
|[[:human genes:s:slc6a17|SLC6A17]]|0.488|
|[[:human genes:n:nol10|NOL10]]|0.485|
|[[:human genes:a:ankle1|ANKLE1]]|0.485|
|[[:human genes:p:psmd11|PSMD11]]|0.484|
|[[:human genes:t:tfip11|TFIP11]]|0.483|
|[[:human genes:p:pbxip1|PBXIP1]]|0.482|
|[[:human genes:c:cope|COPE]]|0.482|
|[[:human genes:t:timeless|TIMELESS]]|0.482|
|[[:human genes:c:cdc6|CDC6]]|0.48|
|[[:human genes:r:rps28|RPS28]]|0.478|
|[[:human genes:v:vps54|VPS54]]|0.477|
|[[:human genes:c:copg1|COPG1]]|0.476|
|[[:human genes:m:myo1h|MYO1H]]|0.476|
|[[:human genes:o:ogfr|OGFR]]|0.474|
|[[:human genes:f:fam160a1|FAM160A1]]|0.472|
|[[:human genes:w:wdr75|WDR75]]|0.472|
|[[:human genes:t:terf1|TERF1]]|0.472|
|[[:human genes:p:pcf11|PCF11]]|0.471|
|[[:human genes:a:aatf|AATF]]|0.471|
|[[:human genes:s:slc4a1|SLC4A1]]|0.47|
|[[:human genes:f:fbxo5|FBXO5]]|0.469|
|[[:human genes:m:mt1e|MT1E]]|0.469|
|[[:human genes:n:nsf|NSF]]|0.469|
|[[:human genes:g:golga6a|GOLGA6A]]|0.467|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.467|
|[[:human genes:s:s1pr4|S1PR4]]|0.466|
|[[:human genes:c:cgb2|CGB2]]|0.466|
|[[:human genes:s:supt6h|SUPT6H]]|0.466|
|[[:human genes:z:znf830|ZNF830]]|0.466|
|[[:human genes:u:utp3|UTP3]]|0.465|
|[[:human genes:p:polr2f|POLR2F]]|0.465|
|[[:human genes:p:psma7|PSMA7]]|0.464|
|[[:human genes:s:scaf1|SCAF1]]|0.462|
|[[:human genes:k:krt78|KRT78]]|0.462|
|[[:human genes:p:polr2d|POLR2D]]|0.461|
|[[:human genes:a:aamp|AAMP]]|0.46|
|[[:human genes:p:pola2|POLA2]]|0.46|
|[[:human genes:n:nfatc4|NFATC4]]|0.46|
|[[:human genes:i:igfn1|IGFN1]]|0.459|
|[[:human genes:r:rrn3|RRN3]]|0.459|
|[[:human genes:g:golga8o|GOLGA8O]]|0.458|
|[[:human genes:c:cmya5|CMYA5]]|0.458|
|[[:human genes:u:utp20|UTP20]]|0.458|
|[[:human genes:c:ccna2|CCNA2]]|0.457|
|[[:human genes:z:znf655|ZNF655]]|0.457|
|[[:human genes:p:psmd3|PSMD3]]|0.457|
|[[:human genes:r:rad21|RAD21]]|0.457|
|[[:human genes:f:fam86b2|FAM86B2]]|0.457|
|[[:human genes:d:ddt|DDT]]|0.456|
|[[:human genes:r:rilpl1|RILPL1]]|0.456|
|[[:human genes:r:ranbp2|RANBP2]]|0.455|
|[[:human genes:g:golga6b|GOLGA6B]]|0.455|
|[[:human genes:c:copa|COPA]]|0.455|
|[[:human genes:k:krt2|KRT2]]|0.455|
|[[:human genes:s:sult1a3|SULT1A3]]|0.454|
|[[:human genes:z:znf541|ZNF541]]|0.453|
|[[:human genes:s:sult1a4|SULT1A4]]|0.453|
|[[:human genes:a:akirin2|AKIRIN2]]|0.452|
|[[:human genes:n:nup133|NUP133]]|0.452|
|[[:human genes:r:rps3a|RPS3A]]|0.452|
|[[:human genes:g:gid4|GID4]]|0.451|
|[[:human genes:t:tspy8|TSPY8]]|0.451|
|[[:human genes:a:ankle2|ANKLE2]]|0.45|
|[[:human genes:l:lrr1|LRR1]]|0.449|
|[[:human genes:c:cdc73|CDC73]]|0.449|
|[[:human genes:r:rpl35|RPL35]]|0.449|
|[[:human genes:e:exosc5|EXOSC5]]|0.448|
|[[:human genes:n:nup160|NUP160]]|0.448|
|[[:human genes:t:tyms|TYMS]]|0.447|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.447|
|[[:human genes:t:tuba8|TUBA8]]|0.447|
|[[:human genes:s:sprr2b|SPRR2B]]|0.447|
|[[:human genes:d:ddx56|DDX56]]|0.447|
|[[:human genes:p:psmb3|PSMB3]]|0.446|
|[[:human genes:e:esf1|ESF1]]|0.446|
|[[:human genes:s:supt5h|SUPT5H]]|0.445|
|[[:human genes:n:nol8|NOL8]]|0.445|
|[[:human genes:l:loc643669|LOC643669]]|0.445|
|[[:human genes:p:psmc2|PSMC2]]|0.444|
|[[:human genes:w:wdr87|WDR87]]|0.443|
|[[:human genes:r:rpl34|RPL34]]|0.442|
|[[:human genes:c:chmp4b|CHMP4B]]|0.442|
|[[:human genes:f:fcn2|FCN2]]|0.441|
|[[:human genes:z:znf106|ZNF106]]|0.441|
|[[:human genes:n:npipb8|NPIPB8]]|0.441|
|[[:human genes:r:rps9|RPS9]]|0.441|
|[[:human genes:o:osbp|OSBP]]|0.44|
|[[:human genes:r:rbbp5|RBBP5]]|0.44|
|[[:human genes:e:elmod3|ELMOD3]]|0.44|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.439|
|[[:human genes:r:rnpc3|RNPC3]]|0.439|
|[[:human genes:p:pan3|PAN3]]|0.439|
|[[:human genes:s:sap30bp|SAP30BP]]|0.439|
|[[:human genes:n:nop16|NOP16]]|0.437|
|[[:human genes:d:disp2|DISP2]]|0.436|
|[[:human genes:t:traip|TRAIP]]|0.436|
|[[:human genes:r:rrp7a|RRP7A]]|0.436|
|[[:human genes:p:polr2j|POLR2J]]|0.435|
|[[:human genes:h:hinfp|HINFP]]|0.435|
|[[:human genes:m:myb|MYB]]|0.435|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.435|
|[[:human genes:c:copb1|COPB1]]|0.434|
|[[:human genes:r:rnf121|RNF121]]|0.433|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.433|
|[[:human genes:m:mki67ip|MKI67IP]]|0.433|
|[[:human genes:a:aqr|AQR]]|0.432|
|[[:human genes:r:rpsa|RPSA]]|0.431|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.43|
|[[:human genes:p:psmc1|PSMC1]]|0.429|
|[[:human genes:a:ahctf1|AHCTF1]]|0.429|
|[[:human genes:t:top1mt|TOP1MT]]|0.429|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.429|
|[[:human genes:c:ccdc116|CCDC116]]|0.429|
|[[:human genes:r:rfpl3|RFPL3]]|0.429|
|[[:human genes:m:myh7b|MYH7B]]|0.428|
|[[:human genes:w:wapal|WAPAL]]|0.428|
|[[:human genes:g:gga3|GGA3]]|0.428|
|[[:human genes:z:zmat5|ZMAT5]]|0.427|
|[[:human genes:b:bysl|BYSL]]|0.427|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.427|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.427|
|[[:human genes:w:wdr43|WDR43]]|0.426|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.426|
|[[:human genes:a:atxn1|ATXN1]]|0.425|
|[[:human genes:p:prr20c|PRR20C]]|0.425|
|[[:human genes:o:orc6|ORC6]]|0.425|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.425|
|[[:human genes:p:prr20a|PRR20A]]|0.425|
|[[:human genes:t:tipin|TIPIN]]|0.424|
|[[:human genes:p:prr20d|PRR20D]]|0.424|
|[[:human genes:p:prr20e|PRR20E]]|0.424|
|[[:human genes:p:prr20b|PRR20B]]|0.424|
|[[:human genes:b:bid|BID]]|0.424|
|[[:human genes:m:med14|MED14]]|0.423|
|[[:human genes:m:map7d1|MAP7D1]]|0.423|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.423|
|[[:human genes:b:brix1|BRIX1]]|0.422|
|[[:human genes:s:smg7|SMG7]]|0.422|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.422|
|[[:human genes:p:pigs|PIGS]]|0.421|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.421|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.421|
|[[:human genes:t:topbp1|TOPBP1]]|0.421|
|[[:human genes:n:ndc80|NDC80]]|0.421|
|[[:human genes:d:dhx38|DHX38]]|0.421|
|[[:human genes:c:chchd3|CHCHD3]]|0.42|
|[[:human genes:c:copb2|COPB2]]|0.42|
|[[:human genes:t:tonsl|TONSL]]|0.42|
|[[:human genes:t:terf2|TERF2]]|0.42|
|[[:human genes:e:exosc9|EXOSC9]]|0.42|
|[[:human genes:r:rnf113a|RNF113A]]|0.419|
|[[:human genes:r:rnf4|RNF4]]|0.419|
|[[:human genes:m:madcam1|MADCAM1]]|0.418|
|[[:human genes:m:mcoln1|MCOLN1]]|0.418|
|[[:human genes:t:tspy1|TSPY1]]|0.418|
|[[:human genes:r:rad51|RAD51]]|0.418|
|[[:human genes:p:pole|POLE]]|0.418|
|[[:human genes:p:psmd14|PSMD14]]|0.418|
|[[:human genes:o:or11h6|OR11H6]]|0.417|
|[[:human genes:s:sema6b|SEMA6B]]|0.417|
|[[:human genes:r:rrp15|RRP15]]|0.417|
|[[:human genes:c:ccdc94|CCDC94]]|0.416|
|[[:human genes:s:snip1|SNIP1]]|0.416|
|[[:human genes:p:polr1a|POLR1A]]|0.416|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.416|
|[[:human genes:m:med15|MED15]]|0.416|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.416|
|[[:human genes:f:fam231a|FAM231A]]|0.416|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.416|
|[[:human genes:f:fam231c|FAM231C]]|0.416|
|[[:human genes:p:pan2|PAN2]]|0.415|
|[[:human genes:d:dido1|DIDO1]]|0.415|
|[[:human genes:d:dock6|DOCK6]]|0.415|
|[[:human genes:s:smg1|SMG1]]|0.415|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.415|
|[[:human genes:p:prpf8|PRPF8]]|0.414|
|[[:human genes:r:rilpl2|RILPL2]]|0.414|
|[[:human genes:p:pwp2|PWP2]]|0.414|
|[[:human genes:a:acsf2|ACSF2]]|0.413|
|[[:human genes:r:riok2|RIOK2]]|0.413|
|[[:human genes:n:nop56|NOP56]]|0.412|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.412|
|[[:human genes:a:acbd4|ACBD4]]|0.411|
|[[:human genes:n:nol12|NOL12]]|0.41|
|[[:human genes:g:gbf1|GBF1]]|0.41|
|[[:human genes:m:mfsd12|MFSD12]]|0.41|
|[[:human genes:r:rpl6|RPL6]]|0.41|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.409|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:t:ttk|TTK]]|0.409|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.408|
|[[:human genes:x:xylt2|XYLT2]]|0.408|
|[[:human genes:s:sf3a3|SF3A3]]|0.408|
|[[:human genes:s:sprr2a|SPRR2A]]|0.407|
|[[:human genes:r:rps5|RPS5]]|0.407|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.407|
|[[:human genes:s:sf3a1|SF3A1]]|0.407|
|[[:human genes:s:sart1|SART1]]|0.407|
|[[:human genes:i:ints5|INTS5]]|0.406|
|[[:human genes:b:brf2|BRF2]]|0.405|
|[[:human genes:h:hivep3|HIVEP3]]|0.405|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.405|
|[[:human genes:c:ctr9|CTR9]]|0.405|
|[[:human genes:p:parp3|PARP3]]|0.404|
|[[:human genes:c:ctage4|CTAGE4]]|0.404|
|[[:human genes:r:rpl14|RPL14]]|0.404|
|[[:human genes:s:syt9|SYT9]]|0.404|
|[[:human genes:p:psma1|PSMA1]]|0.403|
|[[:human genes:a:atp1a3|ATP1A3]]|0.402|
|[[:human genes:n:naaladl1|NAALADL1]]|0.402|
|[[:human genes:d:dand5|DAND5]]|0.401|
|[[:human genes:p:ppfia4|PPFIA4]]|0.401|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.401|
|[[:human genes:s:sec13|SEC13]]|0.401|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.4|
|[[:human genes:v:vps28|VPS28]]|0.4|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 455/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|18/28|
|bone|13/26|
|breast|19/33|
|central nervous system|36/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|13/21|
|liver|13/20|
|lung|38/75|
|lymphocyte|10/16|
|ovary|22/26|
|pancreas|15/24|
|peripheral nervous system|12/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1230
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TWISTNB Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>