======= UBA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBA5
  * **<color #00a2e8>Official Name</color>**: ubiquitin like modifier activating enzyme 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79876|79876]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZZ9|Q9GZZ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610552|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E1-like enzyme which activates UFM1 and SUMO2. {ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ThiF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UFM1 activating enzyme activity|
|protein polyufmylation|
|protein K69-linked ufmylation|
|protein ufmylation|
|regulation of intracellular estrogen receptor signaling pathway|
|regulation of intracellular steroid hormone receptor signaling pathway|
|neuromuscular process|
|response to endoplasmic reticulum stress|
|intracellular membrane-bounded organelle|
|protein modification by small protein conjugation|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|nervous system process|
|ATP binding|
|cellular response to stress|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.87|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.66|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.64|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.4|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.25|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.25|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.04|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.03|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.97|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.88|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.72|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.7|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.71|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.71|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.71|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.73|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.74|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.78|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.8|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.81|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.81|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.81|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.82|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.82|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.84|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.86|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.86|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.89|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.96|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.01|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.03|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.05|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.06|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.11|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.19|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.26|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.34|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.53|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1orf27|C1orf27]]|0.748|
|[[:human genes:u:ufsp2|UFSP2]]|0.735|
|[[:human genes:u:ufm1|UFM1]]|0.703|
|[[:human genes:u:ufl1|UFL1]]|0.702|
|[[:human genes:u:ufc1|UFC1]]|0.688|
|[[:human genes:d:ddrgk1|DDRGK1]]|0.587|
|[[:human genes:a:alg6|ALG6]]|0.551|
|[[:human genes:s:sbds|SBDS]]|0.521|
|[[:human genes:a:alg5|ALG5]]|0.514|
|[[:human genes:u:ube2j1|UBE2J1]]|0.501|
|[[:human genes:a:alg8|ALG8]]|0.494|
|[[:human genes:d:dnajb11|DNAJB11]]|0.491|
|[[:human genes:u:ube2g2|UBE2G2]]|0.491|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.489|
|[[:human genes:s:sec62|SEC62]]|0.485|
|[[:human genes:d:dnajc3|DNAJC3]]|0.481|
|[[:human genes:e:eif1ax|EIF1AX]]|0.48|
|[[:human genes:t:tmed10|TMED10]]|0.475|
|[[:human genes:a:atp5b|ATP5B]]|0.469|
|[[:human genes:a:atp5a1|ATP5A1]]|0.467|
|[[:human genes:s:sec63|SEC63]]|0.464|
|[[:human genes:s:srp14|SRP14]]|0.455|
|[[:human genes:u:urm1|URM1]]|0.454|
|[[:human genes:a:atp5o|ATP5O]]|0.453|
|[[:human genes:u:uap1|UAP1]]|0.453|
|[[:human genes:h:hspd1|HSPD1]]|0.449|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.448|
|[[:human genes:r:rtcb|RTCB]]|0.446|
|[[:human genes:a:alg1|ALG1]]|0.44|
|[[:human genes:m:mbtps2|MBTPS2]]|0.438|
|[[:human genes:e:eny2|ENY2]]|0.437|
|[[:human genes:t:thg1l|THG1L]]|0.437|
|[[:human genes:a:atxn10|ATXN10]]|0.434|
|[[:human genes:d:dolk|DOLK]]|0.433|
|[[:human genes:e:elp3|ELP3]]|0.431|
|[[:human genes:s:ssb|SSB]]|0.43|
|[[:human genes:t:trmt10a|TRMT10A]]|0.429|
|[[:human genes:d:dhrsx|DHRSX]]|0.429|
|[[:human genes:g:gfpt1|GFPT1]]|0.423|
|[[:human genes:d:dohh|DOHH]]|0.423|
|[[:human genes:s:stt3a|STT3A]]|0.421|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.417|
|[[:human genes:m:manf|MANF]]|0.417|
|[[:human genes:c:c7orf26|C7orf26]]|0.416|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.415|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.414|
|[[:human genes:d:dpagt1|DPAGT1]]|0.414|
|[[:human genes:d:derl1|DERL1]]|0.413|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.409|
|[[:human genes:t:triap1|TRIAP1]]|0.407|
|[[:human genes:t:taz|TAZ]]|0.401|
|[[:human genes:g:gmppb|GMPPB]]|0.401|
|[[:human genes:b:bcs1l|BCS1L]]|0.401|
|[[:human genes:a:asun|ASUN]]|0.401|
|[[:human genes:g:gtf3a|GTF3A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 120/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|5/28|
|bone|1/26|
|breast|1/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|8/21|
|liver|8/20|
|lung|12/75|
|lymphocyte|2/16|
|ovary|5/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6386
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBA5 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>