======= UBE2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2A
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7319|7319]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49459|P49459]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/312180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:20061386}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|HULC complex|
|XY body|
|histone H2A ubiquitination|
|hatching|
|organism emergence from protective structure|
|blastocyst hatching|
|protein K11-linked ubiquitination|
|histone ubiquitination|
|ubiquitin conjugating enzyme activity|
|postreplication repair|
|protein K48-linked ubiquitination|
|maternal process involved in female pregnancy|
|protein autoubiquitination|
|blastocyst development|
|chromatin|
|response to UV|
|female pregnancy|
|multi-multicellular organism process|
|nuclear chromatin|
|ubiquitin-protein transferase activity|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|response to light stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|histone modification|
|covalent chromatin modification|
|in utero embryonic development|
|response to radiation|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|protein catabolic process|
|protein ubiquitination|
|chromatin organization|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|embryo development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|response to abiotic stimulus|
|proteolysis|
|reproductive process|
|reproduction|
|ATP binding|
|regulation of cell population proliferation|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-3.09|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.93|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.69|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.65|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.63|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.46|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.38|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.35|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.27|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.25|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.25|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.22|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.15|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.11|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.08|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.05|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.99|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.97|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.92|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.89|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.87|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.86|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.81|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.79|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.78|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.75|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.72|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.71|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.7|
|[[:results:exp539|42°C R08 exp539]]|1.71|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.72|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.04|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|1/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14596
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2A Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>