======= UBE2L3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2L3
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 L3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7332|7332]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68036|P68036]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2L3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2L3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603721|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689, ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21532592}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-protein transferase activator activity|
|protein K11-linked ubiquitination|
|positive regulation of ubiquitin-protein transferase activity|
|positive regulation of protein targeting to mitochondrion|
|ubiquitin conjugating enzyme activity|
|regulation of protein targeting to mitochondrion|
|regulation of ubiquitin-protein transferase activity|
|cellular response to glucocorticoid stimulus|
|positive regulation of establishment of protein localization to mitochondrion|
|cellular response to corticosteroid stimulus|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|ubiquitin ligase complex|
|positive regulation of mitochondrion organization|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|response to glucocorticoid|
|positive regulation of intracellular protein transport|
|response to corticosteroid|
|regulation of mitochondrion organization|
|cellular response to steroid hormone stimulus|
|regulation of protein ubiquitination|
|positive regulation of intracellular transport|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|ubiquitin-protein transferase activity|
|cell cycle phase transition|
|transcription coactivator activity|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|positive regulation of cellular protein localization|
|response to steroid hormone|
|enzyme binding|
|regulation of intracellular transport|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|cellular response to lipid|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|proteolysis involved in cellular protein catabolic process|
|cellular response to hormone stimulus|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|protein catabolic process|
|protein ubiquitination|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|response to lipid|
|cellular macromolecule catabolic process|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|cell cycle process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|ATP binding|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.16|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-2.1|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.08|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.02|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.86|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.73|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.06|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.64|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc101|CCDC101]]|0.534|
|[[:human genes:o:otud5|OTUD5]]|0.533|
|[[:human genes:n:nae1|NAE1]]|0.493|
|[[:human genes:u:ubr5|UBR5]]|0.489|
|[[:human genes:t:tle4|TLE4]]|0.474|
|[[:human genes:v:vcpip1|VCPIP1]]|0.466|
|[[:human genes:t:thoc6|THOC6]]|0.466|
|[[:human genes:m:med25|MED25]]|0.461|
|[[:human genes:a:arih1|ARIH1]]|0.457|
|[[:human genes:a:aars|AARS]]|0.448|
|[[:human genes:h:hhex|HHEX]]|0.446|
|[[:human genes:i:id3|ID3]]|0.444|
|[[:human genes:n:nxt1|NXT1]]|0.44|
|[[:human genes:m:mllt1|MLLT1]]|0.439|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.433|
|[[:human genes:x:xpo6|XPO6]]|0.433|
|[[:human genes:u:uba3|UBA3]]|0.432|
|[[:human genes:m:meaf6|MEAF6]]|0.429|
|[[:human genes:t:trmt5|TRMT5]]|0.427|
|[[:human genes:d:ddx5|DDX5]]|0.426|
|[[:human genes:m:mapk14|MAPK14]]|0.425|
|[[:human genes:f:fli1|FLI1]]|0.423|
|[[:human genes:c:cbx3|CBX3]]|0.419|
|[[:human genes:t:tada1|TADA1]]|0.416|
|[[:human genes:r:rnmt|RNMT]]|0.415|
|[[:human genes:b:bap1|BAP1]]|0.412|
|[[:human genes:t:tada3|TADA3]]|0.412|
|[[:human genes:c:cars|CARS]]|0.409|
|[[:human genes:d:dohh|DOHH]]|0.408|
|[[:human genes:n:nsd1|NSD1]]|0.407|
|[[:human genes:r:rtcb|RTCB]]|0.407|
|[[:human genes:t:tti2|TTI2]]|0.404|
|[[:human genes:b:brpf1|BRPF1]]|0.404|
|[[:human genes:m:med23|MED23]]|0.404|
|[[:human genes:g:glmn|GLMN]]|0.404|
|[[:human genes:x:xpot|XPOT]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 157/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|1/28|
|bone|12/25|
|breast|9/33|
|central nervous system|12/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|7/21|
|liver|4/20|
|lung|16/75|
|lymphocyte|1/14|
|ovary|3/26|
|pancreas|7/24|
|peripheral nervous system|4/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|3/7|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|8/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2058
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2L3 Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>