======= UBE2M =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2M
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9040|9040]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61081|P61081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2M&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2M|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603173|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NEDD8 transferase activity|
|protein neddylation|
|positive regulation of neuron apoptotic process|
|positive regulation of neuron death|
|regulation of neuron apoptotic process|
|ubiquitin-protein transferase activity|
|regulation of neuron death|
|post-translational protein modification|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein ubiquitination|
|positive regulation of cell death|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.74|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.82|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.14|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.2|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.31|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.49|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.58|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nae1|NAE1]]|0.634|
|[[:human genes:u:uba3|UBA3]]|0.62|
|[[:human genes:t:triap1|TRIAP1]]|0.489|
|[[:human genes:u:ube2g2|UBE2G2]]|0.464|
|[[:human genes:t:thg1l|THG1L]]|0.456|
|[[:human genes:d:dr1|DR1]]|0.454|
|[[:human genes:c:cul3|CUL3]]|0.452|
|[[:human genes:s:srp14|SRP14]]|0.45|
|[[:human genes:f:fh|FH]]|0.448|
|[[:human genes:b:bak1|BAK1]]|0.443|
|[[:human genes:r:romo1|ROMO1]]|0.441|
|[[:human genes:p:pmm2|PMM2]]|0.44|
|[[:human genes:r:rptor|RPTOR]]|0.44|
|[[:human genes:d:dohh|DOHH]]|0.434|
|[[:human genes:p:ppp6c|PPP6C]]|0.434|
|[[:human genes:g:glmn|GLMN]]|0.431|
|[[:human genes:p:ppa2|PPA2]]|0.43|
|[[:human genes:w:wdr24|WDR24]]|0.429|
|[[:human genes:r:rnmt|RNMT]]|0.428|
|[[:human genes:r:rabggtb|RABGGTB]]|0.422|
|[[:human genes:t:trmt5|TRMT5]]|0.419|
|[[:human genes:c:crls1|CRLS1]]|0.416|
|[[:human genes:a:atp5h|ATP5H]]|0.415|
|[[:human genes:u:uhrf1|UHRF1]]|0.414|
|[[:human genes:a:alg1|ALG1]]|0.413|
|[[:human genes:f:faf2|FAF2]]|0.411|
|[[:human genes:u:uap1|UAP1]]|0.41|
|[[:human genes:d:ddx6|DDX6]]|0.409|
|[[:human genes:t:trnt1|TRNT1]]|0.408|
|[[:human genes:h:hspd1|HSPD1]]|0.408|
|[[:human genes:g:gfpt1|GFPT1]]|0.407|
|[[:human genes:k:kctd5|KCTD5]]|0.406|
|[[:human genes:a:apaf1|APAF1]]|0.406|
|[[:human genes:m:mfn1|MFN1]]|0.403|
|[[:human genes:b:btaf1|BTAF1]]|0.402|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.402|
|[[:human genes:a:adsl|ADSL]]|0.4|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 673/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|28/28|
|bone|25/26|
|breast|27/33|
|central nervous system|45/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|19/21|
|liver|19/20|
|lung|65/75|
|lymphocyte|16/16|
|ovary|23/26|
|pancreas|22/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 629
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2M Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>