======= UBR5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBR5
  * **<color #00a2e8>Official Name</color>**: ubiquitin protein ligase E3 component n-recognin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51366|51366]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95071|O95071]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBR5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBR5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608413|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PABP|
|zf-UBR|
|HECT|
|E3 UbLigase EDD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of histone H2A K63-linked ubiquitination|
|negative regulation of histone ubiquitination|
|regulation of histone H2A K63-linked ubiquitination|
|negative regulation of protein K63-linked ubiquitination|
|negative regulation of protein polyubiquitination|
|progesterone receptor signaling pathway|
|regulation of histone ubiquitination|
|regulation of protein K63-linked ubiquitination|
|ubiquitin-ubiquitin ligase activity|
|regulation of protein polyubiquitination|
|negative regulation of double-strand break repair|
|negative regulation of DNA repair|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|negative regulation of histone modification|
|protein K48-linked ubiquitination|
|regulation of protein import into nucleus|
|regulation of protein import|
|negative regulation of chromatin organization|
|positive regulation of nucleocytoplasmic transport|
|intracellular steroid hormone receptor signaling pathway|
|negative regulation of protein ubiquitination|
|positive regulation of protein localization to nucleus|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|ubiquitin binding|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of nucleocytoplasmic transport|
|regulation of protein localization to nucleus|
|steroid hormone mediated signaling pathway|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|negative regulation of chromosome organization|
|positive regulation of canonical Wnt signaling pathway|
|regulation of histone modification|
|positive regulation of intracellular protein transport|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|positive regulation of Wnt signaling pathway|
|cellular response to steroid hormone stimulus|
|regulation of chromatin organization|
|regulation of protein ubiquitination|
|positive regulation of intracellular transport|
|regulation of response to DNA damage stimulus|
|ubiquitin protein ligase activity|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|regulation of canonical Wnt signaling pathway|
|protein polyubiquitination|
|positive regulation of cellular protein localization|
|response to steroid hormone|
|regulation of chromosome organization|
|regulation of intracellular transport|
|regulation of DNA metabolic process|
|regulation of Wnt signaling pathway|
|negative regulation of organelle organization|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|DNA repair|
|cellular response to lipid|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to hormone stimulus|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|zinc ion binding|
|response to lipid|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.86|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.92|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.93|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.12|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.28|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.39|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.39|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:otud5|OTUD5]]|0.707|
|[[:human genes:t:tti2|TTI2]]|0.49|
|[[:human genes:u:ube2l3|UBE2L3]]|0.489|
|[[:human genes:v:vcpip1|VCPIP1]]|0.487|
|[[:human genes:t:thoc6|THOC6]]|0.479|
|[[:human genes:t:tle4|TLE4]]|0.472|
|[[:human genes:m:mllt1|MLLT1]]|0.465|
|[[:human genes:m:med23|MED23]]|0.46|
|[[:human genes:c:cbx3|CBX3]]|0.448|
|[[:human genes:m:med13l|MED13L]]|0.448|
|[[:human genes:t:trmt5|TRMT5]]|0.438|
|[[:human genes:x:xpot|XPOT]]|0.437|
|[[:human genes:z:znf608|ZNF608]]|0.436|
|[[:human genes:t:trip12|TRIP12]]|0.434|
|[[:human genes:c:csnk2b|CSNK2B]]|0.434|
|[[:human genes:c:ccdc101|CCDC101]]|0.433|
|[[:human genes:h:hhex|HHEX]]|0.428|
|[[:human genes:c:c16orf72|C16orf72]]|0.427|
|[[:human genes:u:ube2g1|UBE2G1]]|0.42|
|[[:human genes:g:glmn|GLMN]]|0.413|
|[[:human genes:k:kcmf1|KCMF1]]|0.412|
|[[:human genes:m:meaf6|MEAF6]]|0.411|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:t:tti1|TTI1]]|0.409|
|[[:human genes:m:med25|MED25]]|0.407|
|[[:human genes:a:arl14ep|ARL14EP]]|0.407|
|[[:human genes:c:cmtr1|CMTR1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 107/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|1/28|
|bone|4/25|
|breast|6/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|1/21|
|liver|4/20|
|lung|11/75|
|lymphocyte|2/14|
|ovary|6/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|1/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 794
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBR5 Expression in NALM6 Cells: 8.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>