======= UBXN2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBXN2B
  * **<color #00a2e8>Official Name</color>**: UBX domain protein 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=137886|137886]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14CS0|Q14CS0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBXN2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBXN2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610686|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. {ECO:0000269|PubMed:17141156}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBX|
|SEP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein localization to centrosome|
|positive regulation of mitotic centrosome separation|
|regulation of mitotic centrosome separation|
|regulation of protein localization to centrosome|
|positive regulation of centrosome cycle|
|spindle pole centrosome|
|nuclear envelope reassembly|
|establishment of mitotic spindle orientation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|establishment of spindle localization|
|spindle localization|
|positive regulation of mitotic nuclear division|
|nuclear envelope organization|
|regulation of centrosome cycle|
|autophagosome assembly|
|autophagosome organization|
|positive regulation of nuclear division|
|ubiquitin binding|
|microtubule cytoskeleton organization involved in mitosis|
|negative regulation of cellular protein localization|
|establishment of cell polarity|
|vacuole organization|
|membrane fusion|
|Golgi organization|
|nucleus organization|
|positive regulation of mitotic cell cycle|
|macroautophagy|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|establishment or maintenance of cell polarity|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|autophagy|
|process utilizing autophagic mechanism|
|positive regulation of cell cycle process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|establishment of organelle localization|
|positive regulation of cell cycle|
|endomembrane system organization|
|microtubule cytoskeleton organization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|modification-dependent macromolecule catabolic process|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|protein catabolic process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|membrane organization|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|Golgi apparatus|
|cell cycle process|
|endoplasmic reticulum|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.92|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.82|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13019
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBXN2B Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>