======= UBXN7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBXN7
  * **<color #00a2e8>Official Name</color>**: UBX domain protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26043|26043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94888|O94888]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBXN7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBXN7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616379|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|VCP-NPL4-UFD1 AAA ATPase complex|
|ubiquitin binding|
|nuclear body|
|ubiquitin protein ligase binding|
|transcription factor binding|
|post-translational protein modification|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.83|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.05|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.1|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.4|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.42|
|[[:results:exp360|Genistein 15μM R07 exp360]]|3.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rad23b|RAD23B]]|0.491|
|[[:human genes:p:plaa|PLAA]]|0.422|
|[[:human genes:t:top2b|TOP2B]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14643
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBXN7 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>