======= UCHL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UCHL1
  * **<color #00a2e8>Official Name</color>**: ubiquitin C-terminal hydrolase L1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7345|7345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09936|P09936]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UCHL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UCHL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191342|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. {ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:9790970}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|omega peptidase activity|
|axon target recognition|
|alpha-2A adrenergic receptor binding|
|axonal transport of mitochondrion|
|ligase activity|
|neuron projection terminus|
|establishment of mitochondrion localization, microtubule-mediated|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization|
|adult walking behavior|
|eating behavior|
|walking behavior|
|mitochondrion localization|
|response to ischemia|
|thiol-dependent ubiquitinyl hydrolase activity|
|axonal transport|
|axon cytoplasm|
|muscle fiber development|
|axo-dendritic transport|
|sensory perception of pain|
|negative regulation of MAP kinase activity|
|adult locomotory behavior|
|organelle transport along microtubule|
|ubiquitin binding|
|feeding behavior|
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|neuromuscular process|
|negative regulation of protein serine/threonine kinase activity|
|striated muscle cell development|
|adult behavior|
|muscle cell development|
|transport along microtubule|
|negative regulation of MAPK cascade|
|regulation of macroautophagy|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|locomotory behavior|
|striated muscle cell differentiation|
|negative regulation of protein kinase activity|
|muscle cell differentiation|
|negative regulation of kinase activity|
|microtubule-based movement|
|negative regulation of transferase activity|
|protein deubiquitination|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of autophagy|
|regulation of MAP kinase activity|
|proteasomal protein catabolic process|
|establishment of organelle localization|
|axonogenesis|
|neuronal cell body|
|negative regulation of protein phosphorylation|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of phosphorylation|
|muscle structure development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|negative regulation of intracellular signal transduction|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|neuron projection development|
|microtubule-based process|
|protein catabolic process|
|cell morphogenesis|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|sensory perception|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|regulation of protein phosphorylation|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.441|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6915
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UCHL1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>