======= UCHL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UCHL5
  * **<color #00a2e8>Official Name</color>**: ubiquitin C-terminal hydrolase L5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51377|51377]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5K5|Q9Y5K5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UCHL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UCHL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610667|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ino80 complex|
|proteasome binding|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|endopeptidase inhibitor activity|
|negative regulation of ubiquitin-dependent protein catabolic process|
|proteasome complex|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of cellular protein catabolic process|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|DNA recombination|
|negative regulation of endopeptidase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|protein deubiquitination|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of proteolysis|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|RNA binding|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-3.19|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.62|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.05|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.92|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.83|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.83|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.8|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.78|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.71|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.76|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.78|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.92|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.96|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.99|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.02|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.08|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.1|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.22|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.22|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.25|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.33|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.42|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.62|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.88|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.11|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|3.18|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|4.32|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|4.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nfrkb|NFRKB]]|0.784|
|[[:human genes:t:tfpt|TFPT]]|0.578|
|[[:human genes:i:ino80e|INO80E]]|0.568|
|[[:human genes:a:actr5|ACTR5]]|0.553|
|[[:human genes:i:ino80|INO80]]|0.543|
|[[:human genes:p:pih1d1|PIH1D1]]|0.46|
|[[:human genes:i:ino80c|INO80C]]|0.435|
|[[:human genes:i:ino80b|INO80B]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6664
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UCHL5 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>