======= UHMK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UHMK1
  * **<color #00a2e8>Official Name</color>**: U2AF homology motif kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=127933|127933]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAS1|Q8TAS1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UHMK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UHMK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuronal ribonucleoprotein granule|
|positive regulation of translational initiation|
|dendrite cytoplasm|
|ribonucleoprotein complex binding|
|regulation of protein export from nucleus|
|transferase activity|
|regulation of translational initiation|
|regulation of nucleocytoplasmic transport|
|positive regulation of translation|
|cell cycle arrest|
|positive regulation of cellular amide metabolic process|
|peptidyl-serine phosphorylation|
|protein autophosphorylation|
|peptidyl-serine modification|
|regulation of intracellular protein transport|
|axon|
|regulation of intracellular transport|
|regulation of translation|
|protein serine/threonine kinase activity|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|neuron projection development|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|neuron development|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein phosphorylation|
|Golgi apparatus|
|cell cycle process|
|neuron differentiation|
|regulation of protein localization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|phosphorylation|
|cell cycle|
|RNA binding|
|ATP binding|
|generation of neurons|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp218|A-395 10μM R05 exp218]]|1.76|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.81|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UHMK1 Expression in NALM6 Cells: 7.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>