======= UHRF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UHRF1
  * **<color #00a2e8>Official Name</color>**: ubiquitin like with PHD and ring finger domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29128|29128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96T88|Q96T88]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UHRF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UHRF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|ubiquitin|
|DUF3590|
|YDG SRA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hemi-methylated DNA-binding|
|nucleosomal histone binding|
|regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|maintenance of DNA methylation|
|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|euchromatin|
|positive regulation of isomerase activity|
|regulation of isomerase activity|
|nuclear heterochromatin|
|replication fork|
|heterochromatin|
|methyl-CpG binding|
|histone monoubiquitination|
|proximal promoter sequence-specific DNA binding|
|histone ubiquitination|
|positive regulation of ATPase activity|
|methylated histone binding|
|protein monoubiquitination|
|protein autoubiquitination|
|regulation of ATPase activity|
|nuclear matrix|
|histone binding|
|ubiquitin protein ligase activity|
|nuclear chromatin|
|ubiquitin-protein transferase activity|
|regulation of epithelial cell proliferation|
|histone modification|
|covalent chromatin modification|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|chromatin organization|
|DNA metabolic process|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.68|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.67|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.6|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-2.57|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.48|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.39|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.38|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.36|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.36|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.35|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.22|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.19|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.19|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-2.19|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.11|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.11|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-2.1|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.09|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.08|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.08|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.07|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.07|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.06|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.05|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.04|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.04|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.01|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.01|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.95|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.93|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.91|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.9|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.9|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.9|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.89|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.89|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.88|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.88|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.88|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.87|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.85|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.83|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.83|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.82|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.8|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.79|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.79|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.78|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.77|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.76|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.75|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.73|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.73|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.72|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.72|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.71|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.71|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.7|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.71|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.71|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.72|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.75|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.79|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.81|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.83|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.08|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.13|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.16|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.87|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg1|ALG1]]|0.661|
|[[:human genes:t:thg1l|THG1L]]|0.647|
|[[:human genes:p:pmm2|PMM2]]|0.631|
|[[:human genes:d:dpagt1|DPAGT1]]|0.603|
|[[:human genes:r:rptor|RPTOR]]|0.603|
|[[:human genes:u:uap1|UAP1]]|0.599|
|[[:human genes:h:hars|HARS]]|0.582|
|[[:human genes:r:rtcb|RTCB]]|0.581|
|[[:human genes:r:rnmt|RNMT]]|0.577|
|[[:human genes:g:gfpt1|GFPT1]]|0.576|
|[[:human genes:t:triap1|TRIAP1]]|0.565|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.562|
|[[:human genes:y:yars|YARS]]|0.56|
|[[:human genes:r:rpp21|RPP21]]|0.56|
|[[:human genes:a:atxn10|ATXN10]]|0.559|
|[[:human genes:g:gmppb|GMPPB]]|0.558|
|[[:human genes:v:vezt|VEZT]]|0.557|
|[[:human genes:f:fh|FH]]|0.554|
|[[:human genes:a:alg13|ALG13]]|0.553|
|[[:human genes:d:dohh|DOHH]]|0.552|
|[[:human genes:s:srp14|SRP14]]|0.547|
|[[:human genes:p:ppcs|PPCS]]|0.547|
|[[:human genes:a:adsl|ADSL]]|0.545|
|[[:human genes:c:cbfb|CBFB]]|0.545|
|[[:human genes:s:slc25a26|SLC25A26]]|0.545|
|[[:human genes:l:lsm10|LSM10]]|0.545|
|[[:human genes:d:dhps|DHPS]]|0.536|
|[[:human genes:g:gnb1l|GNB1L]]|0.536|
|[[:human genes:n:nae1|NAE1]]|0.535|
|[[:human genes:o:osgep|OSGEP]]|0.534|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.533|
|[[:human genes:g:gemin6|GEMIN6]]|0.531|
|[[:human genes:t:ten1|TEN1]]|0.53|
|[[:human genes:g:gemin8|GEMIN8]]|0.527|
|[[:human genes:t:tti1|TTI1]]|0.525|
|[[:human genes:w:wdr24|WDR24]]|0.519|
|[[:human genes:p:pelo|PELO]]|0.517|
|[[:human genes:p:ppp4c|PPP4C]]|0.515|
|[[:human genes:t:trmt5|TRMT5]]|0.515|
|[[:human genes:e:elac2|ELAC2]]|0.51|
|[[:human genes:l:lsm11|LSM11]]|0.509|
|[[:human genes:n:nbn|NBN]]|0.508|
|[[:human genes:c:ccdc101|CCDC101]]|0.505|
|[[:human genes:u:utp23|UTP23]]|0.498|
|[[:human genes:m:med16|MED16]]|0.497|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.497|
|[[:human genes:b:bap1|BAP1]]|0.496|
|[[:human genes:t:tmem41b|TMEM41B]]|0.493|
|[[:human genes:r:rfk|RFK]]|0.492|
|[[:human genes:p:ppp6c|PPP6C]]|0.49|
|[[:human genes:u:uxt|UXT]]|0.49|
|[[:human genes:r:rpe|RPE]]|0.49|
|[[:human genes:r:rpia|RPIA]]|0.489|
|[[:human genes:z:zrsr2|ZRSR2]]|0.488|
|[[:human genes:c:ctc1|CTC1]]|0.486|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.485|
|[[:human genes:d:ddx20|DDX20]]|0.484|
|[[:human genes:e:eny2|ENY2]]|0.483|
|[[:human genes:c:chchd4|CHCHD4]]|0.483|
|[[:human genes:e:eif3f|EIF3F]]|0.483|
|[[:human genes:r:romo1|ROMO1]]|0.48|
|[[:human genes:c:cct7|CCT7]]|0.48|
|[[:human genes:a:alg5|ALG5]]|0.478|
|[[:human genes:m:mrps33|MRPS33]]|0.476|
|[[:human genes:a:atp5j|ATP5J]]|0.474|
|[[:human genes:d:dolk|DOLK]]|0.473|
|[[:human genes:e:exoc4|EXOC4]]|0.473|
|[[:human genes:t:tgs1|TGS1]]|0.473|
|[[:human genes:t:taz|TAZ]]|0.472|
|[[:human genes:e:eno1|ENO1]]|0.47|
|[[:human genes:w:wdr59|WDR59]]|0.47|
|[[:human genes:g:gemin7|GEMIN7]]|0.47|
|[[:human genes:m:mrps14|MRPS14]]|0.469|
|[[:human genes:t:thoc6|THOC6]]|0.468|
|[[:human genes:m:mllt1|MLLT1]]|0.468|
|[[:human genes:s:slc25a19|SLC25A19]]|0.468|
|[[:human genes:h:haus8|HAUS8]]|0.467|
|[[:human genes:e:eif4e|EIF4E]]|0.467|
|[[:human genes:m:med23|MED23]]|0.466|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.465|
|[[:human genes:m:mtor|MTOR]]|0.464|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.464|
|[[:human genes:a:atp5o|ATP5O]]|0.464|
|[[:human genes:u:uba3|UBA3]]|0.461|
|[[:human genes:p:polr3h|POLR3H]]|0.459|
|[[:human genes:t:trnt1|TRNT1]]|0.459|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.459|
|[[:human genes:t:tbcb|TBCB]]|0.457|
|[[:human genes:d:dr1|DR1]]|0.457|
|[[:human genes:r:rbmx2|RBMX2]]|0.456|
|[[:human genes:s:snapc5|SNAPC5]]|0.456|
|[[:human genes:t:telo2|TELO2]]|0.456|
|[[:human genes:m:med4|MED4]]|0.455|
|[[:human genes:m:mrps34|MRPS34]]|0.454|
|[[:human genes:t:tufm|TUFM]]|0.451|
|[[:human genes:e:eprs|EPRS]]|0.45|
|[[:human genes:t:tprkb|TPRKB]]|0.449|
|[[:human genes:s:ssb|SSB]]|0.448|
|[[:human genes:t:tamm41|TAMM41]]|0.448|
|[[:human genes:c:cbx3|CBX3]]|0.448|
|[[:human genes:d:ddx39a|DDX39A]]|0.448|
|[[:human genes:t:trmt10a|TRMT10A]]|0.447|
|[[:human genes:t:tti2|TTI2]]|0.446|
|[[:human genes:t:tsen54|TSEN54]]|0.443|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.442|
|[[:human genes:s:sars2|SARS2]]|0.442|
|[[:human genes:p:ppa2|PPA2]]|0.441|
|[[:human genes:u:ube2g2|UBE2G2]]|0.441|
|[[:human genes:t:tbca|TBCA]]|0.441|
|[[:human genes:c:csnk2b|CSNK2B]]|0.439|
|[[:human genes:p:pggt1b|PGGT1B]]|0.438|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.437|
|[[:human genes:h:hspd1|HSPD1]]|0.436|
|[[:human genes:a:alg2|ALG2]]|0.436|
|[[:human genes:t:txnl4b|TXNL4B]]|0.435|
|[[:human genes:f:fnta|FNTA]]|0.433|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.433|
|[[:human genes:d:dhrsx|DHRSX]]|0.432|
|[[:human genes:g:gemin5|GEMIN5]]|0.431|
|[[:human genes:m:mapk14|MAPK14]]|0.43|
|[[:human genes:n:nars|NARS]]|0.429|
|[[:human genes:c:c15orf41|C15orf41]]|0.429|
|[[:human genes:a:atp5h|ATP5H]]|0.428|
|[[:human genes:d:dhx29|DHX29]]|0.428|
|[[:human genes:v:vmp1|VMP1]]|0.427|
|[[:human genes:g:gpn2|GPN2]]|0.426|
|[[:human genes:t:taf1a|TAF1A]]|0.425|
|[[:human genes:r:rft1|RFT1]]|0.424|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.424|
|[[:human genes:t:ttc4|TTC4]]|0.424|
|[[:human genes:d:dpf2|DPF2]]|0.424|
|[[:human genes:t:tpk1|TPK1]]|0.424|
|[[:human genes:k:kctd5|KCTD5]]|0.42|
|[[:human genes:d:ddx55|DDX55]]|0.419|
|[[:human genes:y:yars2|YARS2]]|0.419|
|[[:human genes:w:wdr1|WDR1]]|0.419|
|[[:human genes:c:cep57|CEP57]]|0.419|
|[[:human genes:a:aars|AARS]]|0.418|
|[[:human genes:c:crls1|CRLS1]]|0.418|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.417|
|[[:human genes:p:pik3r4|PIK3R4]]|0.417|
|[[:human genes:c:c17orf89|C17orf89]]|0.417|
|[[:human genes:m:maml1|MAML1]]|0.416|
|[[:human genes:a:atp5b|ATP5B]]|0.416|
|[[:human genes:z:zcrb1|ZCRB1]]|0.415|
|[[:human genes:e:eef1e1|EEF1E1]]|0.415|
|[[:human genes:t:timm13|TIMM13]]|0.415|
|[[:human genes:u:ube2m|UBE2M]]|0.414|
|[[:human genes:n:nsmce1|NSMCE1]]|0.413|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.412|
|[[:human genes:w:wdr82|WDR82]]|0.412|
|[[:human genes:t:tsen34|TSEN34]]|0.411|
|[[:human genes:r:rad1|RAD1]]|0.41|
|[[:human genes:o:orc5|ORC5]]|0.41|
|[[:human genes:a:atic|ATIC]]|0.41|
|[[:human genes:v:vrk1|VRK1]]|0.409|
|[[:human genes:m:mrps18a|MRPS18A]]|0.409|
|[[:human genes:a:alg6|ALG6]]|0.409|
|[[:human genes:e:eed|EED]]|0.408|
|[[:human genes:n:ndufb1|NDUFB1]]|0.408|
|[[:human genes:p:psmg4|PSMG4]]|0.407|
|[[:human genes:h:hccs|HCCS]]|0.406|
|[[:human genes:t:txnrd1|TXNRD1]]|0.405|
|[[:human genes:x:xrcc2|XRCC2]]|0.404|
|[[:human genes:o:oip5|OIP5]]|0.404|
|[[:human genes:r:rad50|RAD50]]|0.404|
|[[:human genes:c:crcp|CRCP]]|0.404|
|[[:human genes:b:bcs1l|BCS1L]]|0.402|
|[[:human genes:d:dars2|DARS2]]|0.401|
|[[:human genes:s:srd5a3|SRD5A3]]|0.401|
|[[:human genes:g:gfm1|GFM1]]|0.401|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2917
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UHRF1 Expression in NALM6 Cells: 8.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>