======= UPF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UPF2
  * **<color #00a2e8>Official Name</color>**: UPF2 regulator of nonsense mediated mRNA decay
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26019|26019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAU5|Q9HAU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UPF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UPF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605529|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIF4G|
|Upf2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exon-exon junction complex|
|telomeric DNA binding|
|polysome|
|cytoplasmic ribonucleoprotein granule|
|animal organ regeneration|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|liver development|
|RNA export from nucleus|
|hepaticobiliary system development|
|protein export from nucleus|
|mRNA transport|
|regeneration|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|RNA localization|
|mRNA catabolic process|
|nucleobase-containing compound transport|
|RNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|nucleobase-containing compound catabolic process|
|gland development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.04|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.69|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.55|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.07|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.07|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2|
|[[:results:exp135|MS023 7μM R03 exp135]]|-2|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.94|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.94|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.84|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.83|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.82|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.8|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.71|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.7|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.73|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.74|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.77|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.87|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.1|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.11|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 557/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|21/28|
|bone|21/26|
|breast|19/33|
|central nervous system|39/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|14/21|
|liver|12/20|
|lung|55/75|
|lymphocyte|15/16|
|ovary|22/26|
|pancreas|21/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 201
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UPF2 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>