======= UPP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UPP1
  * **<color #00a2e8>Official Name</color>**: uridine phosphorylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7378|7378]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16831|Q16831]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UPP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UPP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:7488099, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PNP UDP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uridine catabolic process|
|uridine phosphorylase activity|
|uridine metabolic process|
|pyrimidine nucleotide salvage|
|pyrimidine ribonucleotide salvage|
|UMP salvage|
|UMP metabolic process|
|pyrimidine ribonucleoside monophosphate metabolic process|
|UMP biosynthetic process|
|pyrimidine ribonucleoside monophosphate biosynthetic process|
|pyrimidine-containing compound salvage|
|pyrimidine nucleoside salvage|
|pyrimidine ribonucleoside catabolic process|
|nucleotide salvage|
|pyrimidine ribonucleoside metabolic process|
|pyrimidine nucleoside biosynthetic process|
|pyrimidine nucleoside monophosphate biosynthetic process|
|nucleoside salvage|
|pyrimidine nucleoside monophosphate metabolic process|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine nucleoside catabolic process|
|ribonucleoside catabolic process|
|pyrimidine ribonucleotide metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|cellular metabolic compound salvage|
|nucleoside catabolic process|
|pyrimidine nucleoside metabolic process|
|nucleoside biosynthetic process|
|cellular response to glucose starvation|
|glycosyl compound biosynthetic process|
|pyrimidine-containing compound catabolic process|
|nucleoside monophosphate biosynthetic process|
|glycosyl compound catabolic process|
|pyrimidine nucleotide biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|nucleobase-containing small molecule catabolic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|organophosphate catabolic process|
|glycosyl compound metabolic process|
|cellular response to starvation|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|carbohydrate derivative catabolic process|
|response to starvation|
|cellular response to nutrient levels|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular response to extracellular stimulus|
|ribonucleotide metabolic process|
|cellular response to external stimulus|
|ribose phosphate metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.9|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.99|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.23|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17343
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UPP1 Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>