======= URM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: URM1
  * **<color #00a2e8>Official Name</color>**: ubiquitin related modifier 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81605|81605]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTM9|Q9BTM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=URM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20URM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612693|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {ECO:0000255|HAMAP- Rule:MF_03048, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:21209336}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Urm1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sulfur carrier activity|
|protein urmylation|
|tRNA thio-modification|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|protein modification by small protein conjugation|
|RNA processing|
|protein modification by small protein conjugation or removal|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.17|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.82|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.81|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.73|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.7|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.71|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.74|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.76|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.76|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.77|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.97|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.98|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.99|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.01|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.03|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.05|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.06|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.14|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.19|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.38|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.41|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.42|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.57|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.67|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.79|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mocs3|MOCS3]]|0.777|
|[[:human genes:c:ctu1|CTU1]]|0.774|
|[[:human genes:e:elp3|ELP3]]|0.768|
|[[:human genes:e:elp2|ELP2]]|0.733|
|[[:human genes:e:elp6|ELP6]]|0.709|
|[[:human genes:c:ctu2|CTU2]]|0.669|
|[[:human genes:k:kti12|KTI12]]|0.651|
|[[:human genes:d:dph3|DPH3]]|0.635|
|[[:human genes:e:elp4|ELP4]]|0.62|
|[[:human genes:t:thg1l|THG1L]]|0.603|
|[[:human genes:r:rpp21|RPP21]]|0.552|
|[[:human genes:a:atic|ATIC]]|0.535|
|[[:human genes:d:dohh|DOHH]]|0.534|
|[[:human genes:s:ssb|SSB]]|0.53|
|[[:human genes:e:elp5|ELP5]]|0.525|
|[[:human genes:a:adsl|ADSL]]|0.517|
|[[:human genes:r:rptor|RPTOR]]|0.509|
|[[:human genes:i:ikbkap|IKBKAP]]|0.506|
|[[:human genes:u:uap1|UAP1]]|0.504|
|[[:human genes:t:tsen54|TSEN54]]|0.501|
|[[:human genes:a:atxn10|ATXN10]]|0.501|
|[[:human genes:d:dhrsx|DHRSX]]|0.5|
|[[:human genes:s:srp14|SRP14]]|0.5|
|[[:human genes:r:rpe|RPE]]|0.496|
|[[:human genes:a:alg1|ALG1]]|0.493|
|[[:human genes:p:pdap1|PDAP1]]|0.491|
|[[:human genes:c:c15orf41|C15orf41]]|0.49|
|[[:human genes:d:dph1|DPH1]]|0.489|
|[[:human genes:n:n6amt1|N6AMT1]]|0.488|
|[[:human genes:t:tkt|TKT]]|0.486|
|[[:human genes:s:sbds|SBDS]]|0.484|
|[[:human genes:c:c14orf80|C14orf80]]|0.483|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.482|
|[[:human genes:d:dpagt1|DPAGT1]]|0.481|
|[[:human genes:a:alkbh8|ALKBH8]]|0.479|
|[[:human genes:a:asun|ASUN]]|0.479|
|[[:human genes:k:kdm8|KDM8]]|0.478|
|[[:human genes:b:bcs1l|BCS1L]]|0.477|
|[[:human genes:r:rpia|RPIA]]|0.473|
|[[:human genes:s:sec62|SEC62]]|0.471|
|[[:human genes:d:ddx1|DDX1]]|0.471|
|[[:human genes:v:vezt|VEZT]]|0.471|
|[[:human genes:g:gmppb|GMPPB]]|0.47|
|[[:human genes:d:dph5|DPH5]]|0.469|
|[[:human genes:r:rtcb|RTCB]]|0.469|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.464|
|[[:human genes:f:fh|FH]]|0.464|
|[[:human genes:p:pmm2|PMM2]]|0.462|
|[[:human genes:d:dr1|DR1]]|0.462|
|[[:human genes:t:tube1|TUBE1]]|0.461|
|[[:human genes:m:msto1|MSTO1]]|0.459|
|[[:human genes:w:wdr59|WDR59]]|0.459|
|[[:human genes:l:lsm11|LSM11]]|0.459|
|[[:human genes:k:kdsr|KDSR]]|0.458|
|[[:human genes:d:dolk|DOLK]]|0.456|
|[[:human genes:e:exoc4|EXOC4]]|0.456|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.456|
|[[:human genes:u:uba5|UBA5]]|0.454|
|[[:human genes:s:slc7a1|SLC7A1]]|0.453|
|[[:human genes:g:gemin8|GEMIN8]]|0.453|
|[[:human genes:e:eef1e1|EEF1E1]]|0.453|
|[[:human genes:t:trmt10a|TRMT10A]]|0.453|
|[[:human genes:e:eif3f|EIF3F]]|0.452|
|[[:human genes:g:gemin6|GEMIN6]]|0.452|
|[[:human genes:s:srpk1|SRPK1]]|0.452|
|[[:human genes:t:txnl4b|TXNL4B]]|0.452|
|[[:human genes:t:trnt1|TRNT1]]|0.45|
|[[:human genes:a:asb3|ASB3]]|0.448|
|[[:human genes:f:fam98b|FAM98B]]|0.447|
|[[:human genes:t:tubd1|TUBD1]]|0.445|
|[[:human genes:s:slc25a19|SLC25A19]]|0.444|
|[[:human genes:a:atp5a1|ATP5A1]]|0.442|
|[[:human genes:p:ppp6c|PPP6C]]|0.441|
|[[:human genes:u:ube2g2|UBE2G2]]|0.44|
|[[:human genes:t:ten1|TEN1]]|0.438|
|[[:human genes:d:dph6|DPH6]]|0.437|
|[[:human genes:p:ppp4c|PPP4C]]|0.436|
|[[:human genes:i:ints10|INTS10]]|0.436|
|[[:human genes:p:pdcd5|PDCD5]]|0.435|
|[[:human genes:e:eftud1|EFTUD1]]|0.434|
|[[:human genes:c:c7orf26|C7orf26]]|0.433|
|[[:human genes:h:haus8|HAUS8]]|0.432|
|[[:human genes:p:pgm3|PGM3]]|0.432|
|[[:human genes:g:gfpt1|GFPT1]]|0.431|
|[[:human genes:u:utp23|UTP23]]|0.431|
|[[:human genes:w:wrb|WRB]]|0.431|
|[[:human genes:g:gemin7|GEMIN7]]|0.43|
|[[:human genes:t:ttc4|TTC4]]|0.43|
|[[:human genes:t:trmt61a|TRMT61A]]|0.429|
|[[:human genes:d:dnlz|DNLZ]]|0.428|
|[[:human genes:c:cxorf56|CXorf56]]|0.428|
|[[:human genes:a:atp5b|ATP5B]]|0.426|
|[[:human genes:a:atp2b1|ATP2B1]]|0.424|
|[[:human genes:a:atp5o|ATP5O]]|0.422|
|[[:human genes:m:mbtps2|MBTPS2]]|0.421|
|[[:human genes:l:lsm10|LSM10]]|0.42|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.419|
|[[:human genes:d:dusp12|DUSP12]]|0.418|
|[[:human genes:t:triap1|TRIAP1]]|0.416|
|[[:human genes:a:alg6|ALG6]]|0.416|
|[[:human genes:d:dcaf15|DCAF15]]|0.413|
|[[:human genes:p:pmvk|PMVK]]|0.412|
|[[:human genes:t:tpk1|TPK1]]|0.411|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.41|
|[[:human genes:v:vps41|VPS41]]|0.408|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.408|
|[[:human genes:t:trmt5|TRMT5]]|0.408|
|[[:human genes:a:atp5j|ATP5J]]|0.405|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.404|
|[[:human genes:o:osgep|OSGEP]]|0.403|
|[[:human genes:k:kdm3b|KDM3B]]|0.402|
|[[:human genes:e:eny2|ENY2]]|0.402|
|[[:human genes:i:itpa|ITPA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 306/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|11/28|
|bone|13/26|
|breast|8/33|
|central nervous system|36/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|13/21|
|liver|10/20|
|lung|26/75|
|lymphocyte|5/16|
|ovary|12/26|
|pancreas|9/24|
|peripheral nervous system|4/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|14/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2624
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='URM1 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>