======= USP37 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP37
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 37
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57695|57695]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86T82|Q86T82]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP37&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP37|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620226|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein K11-linked deubiquitination|
|protein K48-linked deubiquitination|
|thiol-dependent ubiquitinyl hydrolase activity|
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of DNA replication|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein deubiquitination|
|protein modification by small protein removal|
|protein kinase binding|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|protein catabolic process|
|mitotic cell cycle|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|cell cycle|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.58|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.35|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.25|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.06|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.91|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.87|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.81|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.73|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.7|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.7|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.71|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.73|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.78|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.78|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.8|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.84|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.88|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.91|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.04|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.05|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.05|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.18|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.35|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.58|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.654|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.516|
|[[:human genes:e:exosc2|EXOSC2]]|0.427|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.424|
|[[:human genes:r:rpl30|RPL30]]|0.412|
|[[:human genes:p:ppm1d|PPM1D]]|0.409|
|[[:human genes:r:rpl23a|RPL23A]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/26|
|breast|4/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1931
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP37 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>