======= VANGL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VANGL2
  * **<color #00a2e8>Official Name</color>**: VANGL planar cell polarity protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57216|57216]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULK5|Q9ULK5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VANGL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VANGL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Strabismus|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|non-canonical Wnt signaling pathway involved in heart development|
|lateral sprouting involved in lung morphogenesis|
|cell migration involved in kidney development|
|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis|
|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis|
|cell pole|
|planar cell polarity pathway involved in heart morphogenesis|
|establishment of planar polarity involved in neural tube closure|
|neural plate elongation|
|convergent extension involved in neural plate elongation|
|dichotomous subdivision of terminal units involved in lung branching|
|planar cell polarity pathway involved in axis elongation|
|establishment of body hair or bristle planar orientation|
|serotonergic neuron axon guidance|
|establishment of body hair planar orientation|
|dopaminergic neuron axon guidance|
|Wnt signaling pathway involved in heart development|
|planar cell polarity pathway involved in axon guidance|
|establishment of planar polarity of embryonic epithelium|
|convergent extension involved in axis elongation|
|convergent extension involved in organogenesis|
|muscular septum morphogenesis|
|neural plate morphogenesis|
|convergent extension involved in gastrulation|
|lateral sprouting from an epithelium|
|membranous septum morphogenesis|
|neural plate development|
|dichotomous subdivision of an epithelial terminal unit|
|apical protein localization|
|planar cell polarity pathway involved in neural tube closure|
|convergent extension|
|regulation of establishment of planar polarity involved in neural tube closure|
|regulation of epithelial tube formation|
|post-anal tail morphogenesis|
|establishment of planar polarity|
|somatic stem cell division|
|establishment of tissue polarity|
|cochlea morphogenesis|
|cell surface receptor signaling pathway involved in heart development|
|epithelial tube branching involved in lung morphogenesis|
|axis elongation|
|inner ear receptor cell stereocilium organization|
|heparan sulfate proteoglycan biosynthetic process|
|stem cell division|
|heparan sulfate proteoglycan metabolic process|
|ventricular septum morphogenesis|
|inner ear receptor cell development|
|COPII-coated ER to Golgi transport vesicle|
|lung morphogenesis|
|morphogenesis of a polarized epithelium|
|non-motile cilium assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|digestive tract morphogenesis|
|morphogenesis of an epithelial sheet|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|cochlea development|
|glomerulus development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|lateral plasma membrane|
|heart looping|
|somatic stem cell population maintenance|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|proteoglycan biosynthetic process|
|stress fiber|
|hair follicle development|
|positive regulation of JUN kinase activity|
|ventricular septum development|
|skin epidermis development|
|cardiac septum morphogenesis|
|molting cycle process|
|hair cycle process|
|embryonic heart tube development|
|Rho protein signal transduction|
|muscle tissue morphogenesis|
|kidney morphogenesis|
|muscle organ morphogenesis|
|regulation of JUN kinase activity|
|neural tube closure|
|tube closure|
|hair cycle|
|molting cycle|
|proteoglycan metabolic process|
|Wnt signaling pathway, planar cell polarity pathway|
|inner ear morphogenesis|
|primary neural tube formation|
|neural tube formation|
|cardiac septum development|
|regulation of establishment of planar polarity|
|developmental growth involved in morphogenesis|
|determination of left/right symmetry|
|ear morphogenesis|
|determination of bilateral symmetry|
|embryonic epithelial tube formation|
|specification of symmetry|
|nephron development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of embryonic development|
|digestive tract development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|stem cell population maintenance|
|maintenance of cell number|
|positive regulation of JNK cascade|
|digestive system development|
|morphogenesis of embryonic epithelium|
|tube formation|
|morphogenesis of a branching epithelium|
|gastrulation|
|neural tube development|
|positive regulation of stress-activated MAPK cascade|
|morphogenesis of a branching structure|
|positive regulation of stress-activated protein kinase signaling cascade|
|lung development|
|cardiac chamber development|
|cell-cell junction|
|respiratory tube development|
|regulation of morphogenesis of an epithelium|
|regulation of JNK cascade|
|inner ear development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|anterior/posterior pattern specification|
|ear development|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|Ras protein signal transduction|
|heart morphogenesis|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|axon guidance|
|positive regulation of MAP kinase activity|
|neuron projection guidance|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|muscle organ development|
|epithelial tube morphogenesis|
|urogenital system development|
|apical plasma membrane|
|small GTPase mediated signal transduction|
|glycoprotein biosynthetic process|
|regionalization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|cilium assembly|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|cilium organization|
|axonogenesis|
|skin development|
|glycoprotein metabolic process|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|axon development|
|epidermis development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|muscle structure development|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|heart development|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|carbohydrate derivative biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|neuron projection development|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|organelle assembly|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|animal organ morphogenesis|
|cell migration|
|regulation of transferase activity|
|embryo development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|locomotion|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VANGL2 Expression in NALM6 Cells: 2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>