======= VAPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAPB
  * **<color #00a2e8>Official Name</color>**: VAMP associated protein B and C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9217|9217]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95292|O95292]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605704|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Motile Sperm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FFAT motif binding|
|endoplasmic reticulum membrane organization|
|endoplasmic reticulum-plasma membrane tethering|
|endoplasmic reticulum localization|
|endoplasmic reticulum exit site|
|modulation by virus of host morphology or physiology|
|positive regulation of viral genome replication|
|beta-tubulin binding|
|modification by symbiont of host morphology or physiology|
|IRE1-mediated unfolded protein response|
|endoplasmic reticulum organization|
|positive regulation of viral life cycle|
|COPII-coated vesicle budding|
|Golgi vesicle budding|
|sphingolipid biosynthetic process|
|regulation of viral genome replication|
|vesicle budding from membrane|
|endoplasmic reticulum unfolded protein response|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|cellular response to unfolded protein|
|membrane lipid biosynthetic process|
|regulation of viral life cycle|
|cellular response to topologically incorrect protein|
|sphingolipid metabolic process|
|modification of morphology or physiology of other organism|
|interaction with host|
|response to unfolded protein|
|organelle localization by membrane tethering|
|membrane docking|
|response to topologically incorrect protein|
|membrane lipid metabolic process|
|regulation of viral process|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of symbiosis, encompassing mutualism through parasitism|
|microtubule binding|
|response to endoplasmic reticulum stress|
|vesicle organization|
|cadherin binding|
|enzyme binding|
|Golgi vesicle transport|
|endomembrane system organization|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|positive regulation of multi-organism process|
|cellular metal ion homeostasis|
|lipid biosynthetic process|
|organelle localization|
|Golgi membrane|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|membrane organization|
|protein homodimerization activity|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|endoplasmic reticulum|
|chemical homeostasis|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|homeostatic process|
|cellular response to stress|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.79|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAPB Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>