======= VAV1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAV1
  * **<color #00a2e8>Official Name</color>**: vav guanine nucleotide exchange factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7409|7409]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15498|P15498]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAV1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAV1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164875|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|PH|
|SH2|
|C1 1|
|RhoGEF|
|CH|
|CAMSAP CH|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rac guanyl-nucleotide exchange factor activity|
|positive regulation of natural killer cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated immunity|
|phosphotyrosine residue binding|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|T cell costimulation|
|lymphocyte costimulation|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of Ras protein signal transduction|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of cell killing|
|positive regulation of small GTPase mediated signal transduction|
|regulation of leukocyte mediated cytotoxicity|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|neutrophil migration|
|integrin-mediated signaling pathway|
|granulocyte migration|
|regulation of cell killing|
|guanyl-nucleotide exchange factor activity|
|positive regulation of lymphocyte mediated immunity|
|reactive oxygen species metabolic process|
|myeloid leukocyte migration|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|platelet activation|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of Rho protein signal transduction|
|leukocyte chemotaxis|
|regulation of lymphocyte mediated immunity|
|positive regulation of protein kinase B signaling|
|cell-cell junction|
|Fc-epsilon receptor signaling pathway|
|regulation of cell size|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|cell chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|T cell activation|
|lymphocyte differentiation|
|Fc receptor signaling pathway|
|regulation of Ras protein signal transduction|
|positive regulation of cell-cell adhesion|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|phagocytosis|
|leukocyte differentiation|
|positive regulation of innate immune response|
|regulation of small GTPase mediated signal transduction|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|regulation of cellular component size|
|leukocyte migration|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|regulation of response to biotic stimulus|
|chemotaxis|
|taxis|
|hemopoiesis|
|immune response-activating signal transduction|
|response to wounding|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|positive regulation of immune response|
|leukocyte activation|
|cell migration|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of hydrolase activity|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.72|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nck1|NCK1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5376
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAV1 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>