======= VEZT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VEZT
  * **<color #00a2e8>Official Name</color>**: vezatin, adherens junctions transmembrane protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55591|55591]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBM0|Q9HBM0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VEZT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VEZT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619749|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vezatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stereocilium membrane|
|stereocilia ankle link complex|
|myosin binding|
|adherens junction|
|acrosomal vesicle|
|cell-cell adhesion|
|cell adhesion|
|biological adhesion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.89|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.8|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.78|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.77|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.73|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.7|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2.67|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.61|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.53|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.51|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.5|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.43|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.43|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.43|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.33|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.33|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2.31|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.3|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.28|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.25|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.22|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2.21|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.2|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.18|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-2.18|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.17|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.15|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.14|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.12|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.07|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.03|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.03|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.03|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-2.02|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.99|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.98|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.97|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.93|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.93|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.92|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.91|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.88|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.86|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.85|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.85|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.85|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.83|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.82|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.82|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.77|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.76|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.76|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.76|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.74|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.72|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.72|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.71|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.75|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.81|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.86|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.86|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.91|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.96|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.15|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.16|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.3|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.695|
|[[:human genes:a:atxn10|ATXN10]]|0.671|
|[[:human genes:a:alg1|ALG1]]|0.643|
|[[:human genes:t:triap1|TRIAP1]]|0.615|
|[[:human genes:a:atic|ATIC]]|0.611|
|[[:human genes:d:dpagt1|DPAGT1]]|0.607|
|[[:human genes:r:rpia|RPIA]]|0.601|
|[[:human genes:p:pmm2|PMM2]]|0.6|
|[[:human genes:r:rpp21|RPP21]]|0.595|
|[[:human genes:g:gemin6|GEMIN6]]|0.588|
|[[:human genes:g:gemin8|GEMIN8]]|0.586|
|[[:human genes:d:dohh|DOHH]]|0.578|
|[[:human genes:p:ppcs|PPCS]]|0.575|
|[[:human genes:d:ddx20|DDX20]]|0.574|
|[[:human genes:g:gmppb|GMPPB]]|0.572|
|[[:human genes:r:rnmt|RNMT]]|0.568|
|[[:human genes:u:uap1|UAP1]]|0.566|
|[[:human genes:z:zrsr2|ZRSR2]]|0.56|
|[[:human genes:u:uhrf1|UHRF1]]|0.557|
|[[:human genes:e:exoc4|EXOC4]]|0.555|
|[[:human genes:t:ttc4|TTC4]]|0.555|
|[[:human genes:f:fh|FH]]|0.552|
|[[:human genes:s:slc25a26|SLC25A26]]|0.549|
|[[:human genes:t:ten1|TEN1]]|0.543|
|[[:human genes:g:gemin7|GEMIN7]]|0.543|
|[[:human genes:a:alg13|ALG13]]|0.536|
|[[:human genes:r:rfk|RFK]]|0.53|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.528|
|[[:human genes:a:adsl|ADSL]]|0.527|
|[[:human genes:g:gfpt1|GFPT1]]|0.525|
|[[:human genes:s:slc25a19|SLC25A19]]|0.523|
|[[:human genes:t:tbcb|TBCB]]|0.522|
|[[:human genes:t:tsen54|TSEN54]]|0.521|
|[[:human genes:s:srd5a3|SRD5A3]]|0.521|
|[[:human genes:r:rtcb|RTCB]]|0.519|
|[[:human genes:s:srp14|SRP14]]|0.518|
|[[:human genes:d:dhps|DHPS]]|0.513|
|[[:human genes:e:elac2|ELAC2]]|0.512|
|[[:human genes:n:nae1|NAE1]]|0.511|
|[[:human genes:r:rabggtb|RABGGTB]]|0.509|
|[[:human genes:a:alg2|ALG2]]|0.507|
|[[:human genes:e:exoc3|EXOC3]]|0.506|
|[[:human genes:c:cep57|CEP57]]|0.506|
|[[:human genes:d:dolk|DOLK]]|0.505|
|[[:human genes:d:ddx39a|DDX39A]]|0.504|
|[[:human genes:p:pelo|PELO]]|0.503|
|[[:human genes:k:kdsr|KDSR]]|0.502|
|[[:human genes:t:trnt1|TRNT1]]|0.499|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.499|
|[[:human genes:r:rft1|RFT1]]|0.497|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.495|
|[[:human genes:c:chchd4|CHCHD4]]|0.494|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.493|
|[[:human genes:t:trmt61a|TRMT61A]]|0.492|
|[[:human genes:h:haus8|HAUS8]]|0.492|
|[[:human genes:r:rptor|RPTOR]]|0.491|
|[[:human genes:r:rpe|RPE]]|0.491|
|[[:human genes:d:dars2|DARS2]]|0.49|
|[[:human genes:m:mrps11|MRPS11]]|0.488|
|[[:human genes:d:dnlz|DNLZ]]|0.488|
|[[:human genes:s:sdha|SDHA]]|0.487|
|[[:human genes:u:utp23|UTP23]]|0.483|
|[[:human genes:e:elp2|ELP2]]|0.482|
|[[:human genes:t:txnl4b|TXNL4B]]|0.481|
|[[:human genes:a:atp5j|ATP5J]]|0.481|
|[[:human genes:e:eef1e1|EEF1E1]]|0.479|
|[[:human genes:d:dctn6|DCTN6]]|0.479|
|[[:human genes:a:atp5b|ATP5B]]|0.478|
|[[:human genes:l:lsm10|LSM10]]|0.478|
|[[:human genes:f:fnta|FNTA]]|0.478|
|[[:human genes:r:romo1|ROMO1]]|0.478|
|[[:human genes:d:dhrsx|DHRSX]]|0.477|
|[[:human genes:b:bcs1l|BCS1L]]|0.477|
|[[:human genes:t:trmt5|TRMT5]]|0.477|
|[[:human genes:t:tamm41|TAMM41]]|0.477|
|[[:human genes:h:hspd1|HSPD1]]|0.476|
|[[:human genes:y:yars|YARS]]|0.476|
|[[:human genes:g:gemin5|GEMIN5]]|0.475|
|[[:human genes:b:bap1|BAP1]]|0.475|
|[[:human genes:e:elp3|ELP3]]|0.475|
|[[:human genes:m:mrps14|MRPS14]]|0.474|
|[[:human genes:w:wdr92|WDR92]]|0.474|
|[[:human genes:g:gnb1l|GNB1L]]|0.474|
|[[:human genes:d:ddx1|DDX1]]|0.474|
|[[:human genes:p:ppa2|PPA2]]|0.473|
|[[:human genes:m:mrpl15|MRPL15]]|0.472|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.472|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.472|
|[[:human genes:s:ssb|SSB]]|0.471|
|[[:human genes:u:urm1|URM1]]|0.471|
|[[:human genes:p:ppp6c|PPP6C]]|0.468|
|[[:human genes:c:ctc1|CTC1]]|0.468|
|[[:human genes:t:telo2|TELO2]]|0.468|
|[[:human genes:c:c15orf41|C15orf41]]|0.467|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.467|
|[[:human genes:m:mbtps2|MBTPS2]]|0.465|
|[[:human genes:p:pdcd5|PDCD5]]|0.465|
|[[:human genes:d:dr1|DR1]]|0.464|
|[[:human genes:o:osgep|OSGEP]]|0.463|
|[[:human genes:m:med16|MED16]]|0.463|
|[[:human genes:a:atp5o|ATP5O]]|0.462|
|[[:human genes:h:hccs|HCCS]]|0.462|
|[[:human genes:a:alg5|ALG5]]|0.461|
|[[:human genes:m:msto1|MSTO1]]|0.46|
|[[:human genes:t:txnrd1|TXNRD1]]|0.46|
|[[:human genes:a:alg14|ALG14]]|0.46|
|[[:human genes:m:mrps34|MRPS34]]|0.458|
|[[:human genes:e:eny2|ENY2]]|0.458|
|[[:human genes:t:trmt10a|TRMT10A]]|0.456|
|[[:human genes:t:tbca|TBCA]]|0.456|
|[[:human genes:u:uba3|UBA3]]|0.455|
|[[:human genes:r:rad1|RAD1]]|0.455|
|[[:human genes:t:tufm|TUFM]]|0.451|
|[[:human genes:o:oraov1|ORAOV1]]|0.45|
|[[:human genes:h:hars|HARS]]|0.45|
|[[:human genes:t:tti2|TTI2]]|0.449|
|[[:human genes:t:tsen34|TSEN34]]|0.448|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.447|
|[[:human genes:m:mrps33|MRPS33]]|0.446|
|[[:human genes:p:pgm3|PGM3]]|0.444|
|[[:human genes:g:gpn2|GPN2]]|0.443|
|[[:human genes:a:actr1a|ACTR1A]]|0.441|
|[[:human genes:k:kdm8|KDM8]]|0.441|
|[[:human genes:n:n6amt1|N6AMT1]]|0.44|
|[[:human genes:a:alg6|ALG6]]|0.438|
|[[:human genes:w:wdr59|WDR59]]|0.437|
|[[:human genes:n:naa20|NAA20]]|0.437|
|[[:human genes:u:uqcr10|UQCR10]]|0.437|
|[[:human genes:m:mis18a|MIS18A]]|0.436|
|[[:human genes:m:mocs3|MOCS3]]|0.435|
|[[:human genes:t:tpk1|TPK1]]|0.435|
|[[:human genes:e:eif3f|EIF3F]]|0.435|
|[[:human genes:p:ppp4c|PPP4C]]|0.434|
|[[:human genes:t:tprkb|TPRKB]]|0.432|
|[[:human genes:z:zcrb1|ZCRB1]]|0.431|
|[[:human genes:c:c17orf89|C17orf89]]|0.43|
|[[:human genes:m:mrpl21|MRPL21]]|0.43|
|[[:human genes:r:rbmx2|RBMX2]]|0.43|
|[[:human genes:e:eprs|EPRS]]|0.43|
|[[:human genes:c:cbfb|CBFB]]|0.43|
|[[:human genes:s:sugt1|SUGT1]]|0.429|
|[[:human genes:p:plaa|PLAA]]|0.429|
|[[:human genes:a:atp5a1|ATP5A1]]|0.428|
|[[:human genes:n:nbn|NBN]]|0.426|
|[[:human genes:a:atp5h|ATP5H]]|0.426|
|[[:human genes:o:oip5|OIP5]]|0.425|
|[[:human genes:s:snapc5|SNAPC5]]|0.424|
|[[:human genes:p:pggt1b|PGGT1B]]|0.424|
|[[:human genes:l:lsm11|LSM11]]|0.423|
|[[:human genes:m:mrps16|MRPS16]]|0.423|
|[[:human genes:s:sars2|SARS2]]|0.422|
|[[:human genes:t:tgs1|TGS1]]|0.422|
|[[:human genes:t:tmem41b|TMEM41B]]|0.422|
|[[:human genes:c:cct7|CCT7]]|0.421|
|[[:human genes:m:mrps2|MRPS2]]|0.42|
|[[:human genes:w:wdr24|WDR24]]|0.42|
|[[:human genes:y:yars2|YARS2]]|0.419|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.419|
|[[:human genes:a:atp5d|ATP5D]]|0.419|
|[[:human genes:t:timm13|TIMM13]]|0.416|
|[[:human genes:n:nsmce1|NSMCE1]]|0.416|
|[[:human genes:t:taz|TAZ]]|0.416|
|[[:human genes:s:spr|SPR]]|0.414|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.414|
|[[:human genes:e:eftud1|EFTUD1]]|0.414|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.413|
|[[:human genes:p:pdap1|PDAP1]]|0.413|
|[[:human genes:m:med4|MED4]]|0.412|
|[[:human genes:d:ddx55|DDX55]]|0.412|
|[[:human genes:a:aars|AARS]]|0.411|
|[[:human genes:t:tmem242|TMEM242]]|0.411|
|[[:human genes:c:c11orf57|C11orf57]]|0.41|
|[[:human genes:a:atp5f1|ATP5F1]]|0.41|
|[[:human genes:m:mrps18a|MRPS18A]]|0.409|
|[[:human genes:e:eno1|ENO1]]|0.409|
|[[:human genes:t:taf1a|TAF1A]]|0.408|
|[[:human genes:r:rpusd4|RPUSD4]]|0.408|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.407|
|[[:human genes:s:sec62|SEC62]]|0.407|
|[[:human genes:s:sec61g|SEC61G]]|0.406|
|[[:human genes:c:cbx3|CBX3]]|0.406|
|[[:human genes:c:casp9|CASP9]]|0.406|
|[[:human genes:s:srprb|SRPRB]]|0.405|
|[[:human genes:t:tma16|TMA16]]|0.404|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.403|
|[[:human genes:u:uso1|USO1]]|0.402|
|[[:human genes:s:snf8|SNF8]]|0.401|
|[[:human genes:a:atp5c1|ATP5C1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6836
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VEZT Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>