======= VPS13C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS13C
  * **<color #00a2e8>Official Name</color>**: vacuolar protein sorting 13 homolog C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54832|54832]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q709C8|Q709C8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS13C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS13C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization. {ECO:0000269|PubMed:26942284}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Chorein N|
|DUF1162|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|
|regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|
|protein retention in Golgi apparatus|
|regulation of mitophagy|
|Golgi to endosome transport|
|protein localization to Golgi apparatus|
|protein targeting to vacuole|
|regulation of autophagy of mitochondrion|
|establishment of protein localization to vacuole|
|protein localization to vacuole|
|extrinsic component of membrane|
|maintenance of protein location in cell|
|maintenance of location in cell|
|post-Golgi vesicle-mediated transport|
|maintenance of protein location|
|vacuolar transport|
|cytosolic transport|
|mitochondrial outer membrane|
|maintenance of location|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|regulation of autophagy|
|protein targeting|
|Golgi vesicle transport|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of cellular catabolic process|
|intracellular protein transport|
|regulation of catabolic process|
|regulation of organelle organization|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.15|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.78|
|[[:results:exp539|42°C R08 exp539]]|-1.75|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.73|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.72|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.89|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.9|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13196
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS13C Expression in NALM6 Cells: 8.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>